金匮肾气丸改善抑郁症病人疲劳感的临床研究

发布时间：2018-08-23 20:49

【摘要】：目的探讨金匮肾气丸改善肾虚肝郁型抑郁症病人疲劳感的疗效。方法 60例抑郁症病人按数字表法随机分为研究组(金匮肾气丸方合并草酸艾司西酞普兰治疗)和对照组(草酸艾司西酞普兰治疗),每组30例,对照组给予草酸艾司西酞普兰治疗,开始剂量10 mg/d,2周内增至20 mg/d,每天1次,晨起顿服。研究组在此基础上加用金匮肾气丸(制附片6 g,桂枝12 g,牛膝10 g,车前子15 g,熟地黄10 g,泽泻10 g,山萸肉12 g,淮山药10 g,茯苓30 g,牡丹皮12 g,1日1剂,早晚各1次,每次200 mL),2组均治疗8周。在治疗前及治疗的2、4、8周末分别采用疲劳量表-14(Fatigue Scale-14,FS-14)、疲劳自评量表(Fatigue Self Assessment Scale,FSAS)、汉密尔顿抑郁量表(Hamilton Depression Scale,HAMD)评分,并评价治疗效果。结果研究组总有效率为86.7%,对照组为60%,差异有统计学意义(P=0.039)。研究组FS-14量表评分比较,治疗2周、4周、8周末研究组均低于对照组,差异有统计学意义(P0.01),重复测量方差分析显示,评定时间主效应显著(F=495.021,P=0.000),两组治疗2周末、4周末、8周末的FS-14评分均较治疗前降低,评定时间组别的交互作用显著(F=40.923,P=0.000),组间效应显著(F=17.516,P=0.000)。研究组FSAS量表评分比较,治疗2周、4周、8周末研究组均低于对照组,差异有统计学意义(P0.05),重复测量方差分析显示,评定时间主效应显著(F=2 687.437,P=0.000),2组治疗2周末、4周末、8周末的FSAS评分均较治疗前降低,评定时间组别的交互作用显著(F=574.799,P=0.000),组间效应显著(F=8.087,P=0.006)。研究组HAMD评分治疗2、4、8周末均较对照组降低,差异有统计学意义(P0.05),重复测量方差分析显示,评定时间主效应显著(F=317.61,P=0.000),2组治疗2周末、4周末、8周末的HAMD评分均较治疗前降低,评定时间组别的交互作用显著(F=9.374,P=0.001),组间效应显著(F=4.593,P=0.037)。结论金匮肾气丸治疗伴发疲劳感的抑郁症病人疗效显著,起效更快,值得临床推广应用。
[Abstract]:Objective to investigate the effect of Jinkui Shenqi pills on fatigue of depression patients with kidney deficiency and liver depression. Methods Sixty patients with depression were randomly divided into study group (Jinkui Shenqi pills combined with oxalcitalopram) and control group (30 cases in each group). The control group was treated with estalopram oxalate. The initial dose was increased to 20 mg/d, once a day within 10 mg/d,2. The study group added Jinkui Shenqi pills (6 g of Fu Pian, 12 g of Guizhi, 10 g of Achyranthes bidentata, 15 g of Plantago, 10 g of cooked Rehmannia, 10 g of Rhizoma Alismatis, 12 g of Cornel, 10 g of Huai yam, 30 g of Poria cocos, 12 g of Peony Peel, 1 dose each day and morning and evening). Two groups were treated for 8 weeks. The scores of fatigue scale -14 (Fatigue Scale-14,FS-14), fatigue self-rating scale (Fatigue Self Assessment Scale,FSAS) and Hamilton depression scale (Hamilton Depression Scale,HAMD) were used before treatment and at the end of 8 weeks after treatment. Results the total effective rate of the study group was 86.7 and that of the control group was 60. The difference was statistically significant (P0. 039). The scores of FS-14 in the study group were significantly lower than those in the control group at the end of 2 weeks, 4 weeks and 8 weeks after treatment (P0.01). The main effect of evaluation time was significant (FF495.021 P0. 000). The FS-14 scores of the two groups were lower than those before treatment. The interaction between the two groups was significant (FF40.923 / P0. 000) and the intergroup effect was significant (FF17. 516 / P0. 000). The scores of FSAS in the study group were significantly lower than those in the control group at the end of 2 weeks, 4 weeks and 8 weeks after treatment (P0.05). The FSAS scores of the two groups were significantly lower than those before treatment, the interaction between the two groups was significant (FF574.799P0.000), and the inter-group effect was significant (FF8.087mP0.006). The main effect of the evaluation time was significant (FY26687.437) and the FSAS scores of the two groups were significantly lower than those of the patients before treatment at the end of the week and at the end of the 4th week and the 8th week after treatment (FF574.779 P0. 000). The HAMD score of the study group was significantly lower than that of the control group at the 8th week of treatment (P0.05), and repeated measurement variance analysis showed that the main effect of the evaluation time was significant (F _ (317.61) P _ (0.000) the HAMD scores of the two groups were lower than those of the control group at the end of the 2nd week and the end of the 4th week and the 8th week. The intergroup interaction was significant (F9.374 P0. 001) and the intergroup effect was significant (F4. 593 P0. 037). Conclusion Jingui Shenqi Pill is effective in treating depression patients with fatigue, and it is worth popularizing.
【作者单位】：无锡市精神卫生中心中西医结合精神科;
【基金】：国家中医药管理局中医重点专科(ZJ1001SZ011)~~
【分类号】：R749.4

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