嗅觉功能障碍首发抑郁症患者的弥散张量成像研究
发布时间：2018-08-24 16:03
【摘要】：目的探讨首发抑郁症患者是否合并嗅觉功能障碍,利用弥散张量成像(diffusion tensor imaging,DTI)技术研究嗅觉功能障碍首发抑郁症患者脑白质结构改变及其与抑郁严重程度的相关性。方法选取本院2016年4月至2017年6月首发抑郁症患者37例为研究组,同期性别、年龄及受教育程度相匹配的志愿者38例为对照组,均进行24项汉密尔顿抑郁量表(24-item Hamilton depression rating scale,HDRS24)评分;比较两组嗅觉测试结果的差异。根据嗅觉测试结果,将研究组中17例嗅觉减退的首发抑郁症患者列为研究A组,20例无嗅觉减退的首发抑郁症患者为研究B组,分别对研究A组及研究B组进行DTI扫描,运用基于纤维束示踪的空间统计分析方法(tract-based spatial statistics,TBSS)得到各向异性分数(fractional anisotropy,FA),比较研究A组与研究B组的颅脑FA值差异。结果与对照组比较,首发抑郁症患者嗅觉测试值降低(P0.01);与研究B组比较,研究A组左侧海马、胼胝体膝部FA值降低(P0.01,FDR校正),未发现FA值显著增加区域。研究A组嗅觉测试值与HDRS24量表评分呈负相关(r=-0.519,P=0.033),左侧海马、胼胝体膝部下降的FA值与HDRS24量表评分无显著相关性(r左侧海马=0.163,r胼胝体膝部=-0.104;P0.05)。结论首发抑郁症患者可合并嗅觉功能障碍;嗅觉功能障碍首发抑郁症患者存在相关嗅觉通路的损害,但FA值下降与抑郁严重程度无显著相关性。
[Abstract]:Objective to investigate whether patients with first-episode depression are complicated with olfactory dysfunction and to study the changes of white matter structure in patients with first-episode depression and their correlation with the severity of depression by using diffusion-Zhang Liang imaging (diffusion tensor imaging,DTI) technique. Methods from April 2016 to June 2017, 37 patients with first-episode depression in our hospital were selected as study group and 38 volunteers with matched sex, age and education level as control group. 24 items of Hamilton Depression scale (24-item Hamilton depression rating scale,HDRS24) were scored. The difference of olfactory test results between the two groups was compared. According to the results of olfactory test, 17 first-episode depressive patients with hypoolfaction in the study group were included in the study group A and 20 patients with the first episode depression without olfactory impairment as the study group B. DTI scans were performed on the patients in the study group A and the study group B, respectively. The anisotropic fraction (fractional anisotropy,FA) was obtained by using the spatial statistical analysis method (tract-based spatial statistics,TBSS) based on fiber tracer. The difference of brain FA between group A and group B was compared. Results compared with the control group, the olfactory test value of first-episode depression patients decreased (P0.01), compared with the study group B, the FA value of the left hippocampus and the genu of corpus callosum in group A was decreased (P0.01). No significant increase of FA was found in the patients with first-episode depression. In group A, there was a negative correlation between olfactory test value and HDRS24 scale score (r = -0.519). There was no significant correlation between the FA value of the left hippocampus and the genu of corpus callosum and the score of HDRS24 scale (r left hippocampus 0.163 r = -0.104% P 0.05). Conclusion the patients with first-episode depression may be complicated with olfactory dysfunction, and the patients with first-episode depression have related olfactory pathway damage, but there is no significant correlation between the decrease of FA and the severity of depression.
【作者单位】： 重庆医科大学附属永川医院放射科;
【基金】：重庆市教委科学技术研究项目(KJ1702040) 重庆市科委基础科学与前沿技术研究项目(CSTC2016jcyj A0217)~~
【分类号】：R445.2;R749.4
[Abstract]:Objective to investigate whether patients with first-episode depression are complicated with olfactory dysfunction and to study the changes of white matter structure in patients with first-episode depression and their correlation with the severity of depression by using diffusion-Zhang Liang imaging (diffusion tensor imaging,DTI) technique. Methods from April 2016 to June 2017, 37 patients with first-episode depression in our hospital were selected as study group and 38 volunteers with matched sex, age and education level as control group. 24 items of Hamilton Depression scale (24-item Hamilton depression rating scale,HDRS24) were scored. The difference of olfactory test results between the two groups was compared. According to the results of olfactory test, 17 first-episode depressive patients with hypoolfaction in the study group were included in the study group A and 20 patients with the first episode depression without olfactory impairment as the study group B. DTI scans were performed on the patients in the study group A and the study group B, respectively. The anisotropic fraction (fractional anisotropy,FA) was obtained by using the spatial statistical analysis method (tract-based spatial statistics,TBSS) based on fiber tracer. The difference of brain FA between group A and group B was compared. Results compared with the control group, the olfactory test value of first-episode depression patients decreased (P0.01), compared with the study group B, the FA value of the left hippocampus and the genu of corpus callosum in group A was decreased (P0.01). No significant increase of FA was found in the patients with first-episode depression. In group A, there was a negative correlation between olfactory test value and HDRS24 scale score (r = -0.519). There was no significant correlation between the FA value of the left hippocampus and the genu of corpus callosum and the score of HDRS24 scale (r left hippocampus 0.163 r = -0.104% P 0.05). Conclusion the patients with first-episode depression may be complicated with olfactory dysfunction, and the patients with first-episode depression have related olfactory pathway damage, but there is no significant correlation between the decrease of FA and the severity of depression.
【作者单位】： 重庆医科大学附属永川医院放射科;
【基金】：重庆市教委科学技术研究项目(KJ1702040) 重庆市科委基础科学与前沿技术研究项目(CSTC2016jcyj A0217)~~
【分类号】：R445.2;R749.4
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