210名健康成年人的人格特质与杏仁核和海马体积的相关性研究

发布时间：2018-08-24 20:08

【摘要】：目的在神经科学领域,一些研究证实在正常人群中正常人格特质与不同的大脑区域相关联,大脑某些区域体积的增加和减少都与人格特质变量有显著的联系。既往对人格特质相关脑结构的研究集中在前额叶皮质、腹正中眶额叶皮质、扣带回等大脑区域,很少涉及杏仁核和海马。本研究的目的是探索人格特质与杏仁核和海马体积之间的相关性。方法通过广告招募选取210名健康成年人,男性107例(50.95%),女性103例(49.05%),年龄21-60岁,平均(39.10±12.20)岁,按年龄分布将210名被测者分为四个年龄组。采用大五人格量表简化版(NEO-FFI)和状态-特质焦虑量表(STAI)评估入选对象的人格特质,使用Philips Achieva3.0T磁共振成像(MRI)系统对研究对象进行脑影像检查,获得脑部磁共振三维图像,应用基于体素的形态学测量(VBM)方法获得研究对象的杏仁核和海马体积。结果1.特质焦虑与杏仁核和海马体积呈负相关,第2组男性的特质焦虑与右侧杏仁核体积呈正相关。2.女性的神经质与杏仁核和海马体积呈负相关,男性的神经质与杏仁核和海马体积无相关性。3.女性的外向性与杏仁核海马体积呈正相关,男性的外向性与杏仁核和海马体积无相关性。4.第3组女性的开放性与右侧海马体积呈正相关；第4组男性的开放性与右侧杏仁核体积呈正相关。5.第1组男性的顺从性与杏仁核和海马体积呈正相关,第3组和第4组男性的顺从性与杏仁核和海马体积呈负相关。6.第4组女性的严谨性与杏仁核和海马体积呈正相关,男性的严谨性与杏仁核和海马体积无相关性。结论210名健康成年人的人格特质与杏仁核和海马体积均有相关性,各特质与杏仁核和海马体积均有相关性均有显著的性别和年龄差异性。
[Abstract]:Objective in the field of neuroscience, some studies have shown that normal personality traits are associated with different brain regions in normal population. Previous studies on personality trait related brain structure focused on prefrontal cortex, medial orbital frontal cortex, cingulate gyrus and other brain regions, and rarely involved amygdala and hippocampus. The aim of this study was to explore the correlation between personality traits and amygdala and hippocampal volume. Methods 210 healthy adults were recruited by advertisement, 107 males (50.95%) and 103 females (49.05%), aged 21-60 years with an average age of (39.10 卤12.20) years. According to the age distribution, 210 subjects were divided into four age groups. The personality traits of the subjects were evaluated with the Big five Personality scale (NEO-FFI) and the State-Trait anxiety scale (STAI). Three dimensional brain MRI images were obtained by using the Philips Achieva3.0T MRI (MRI) system. The volume of amygdala and hippocampus were obtained by morphologic measurement of (VBM) based on voxel. Result 1. Trait anxiety was negatively correlated with amygdala and hippocampal volume. In group 2, trait anxiety was positively correlated with right amygdala volume. Female neuroticism was negatively correlated with amygdala and hippocampal volume, while male neuroticism had no correlation with amygdala and hippocampal volume. Female extroversion was positively correlated with amygdala hippocampal volume, while male extroversion had no correlation with amygdala and hippocampal volume. 4. In group 3, the openness of the right hippocampus was positively correlated with the volume of the right amygdala, while that of the male in the fourth group was positively correlated with the volume of the right amygdala. The compliance of the first group was positively correlated with the amygdala and hippocampal volume, while that of the third and fourth groups was negatively correlated with the amygdala and hippocampal volume. In the fourth group, there was a positive correlation between the rigor of the amygdala and hippocampal volume in the female, but no correlation between the rigor of the amygdala and the volume of the hippocampus in the male. Conclusion the personality traits of 210 healthy adults were correlated with amygdala and hippocampal volume, and there were significant gender and age differences between personality traits and amygdala and hippocampal volume.
【学位授予单位】：昆明医科大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R749

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