老年精神分裂症患者前瞻性记忆的损伤阶段初探

发布时间：2018-08-25 15:58

【摘要】：目的:初步探讨老年精神分裂症患者基于事件的前瞻性记忆(EBPM)和基于时间的前瞻性记忆(TBPM)的损伤阶段。方法:选取符合美国精神障碍诊断与统计手册第4版诊断标准住院老年精神分裂症患者41例以及年龄、受教育程度相匹配的正常老年对照55例,采用自行编制的前瞻性记忆实验室范式评估EBPM总分、TBPM总分及各项内部指标得分,使用简明精神病评定量表(BPRS)与简明阴性症状量表(BNSS)评估患者的精神病性症状及阴性症状。采用持续注意测验(CPT)评估被试对信号/噪音的区分度d';采用威斯康星卡片分类测验(WCST)和语义流畅性(CF)评估被试的执行功能,分别记录完成分类数和正确应答数。结果:精神分裂症组EBPM[4(0,8)vs.6(0,8),P0.01]与TBPM得分[2(0,8)vs.6(0,8),P0.01]均低于对照组;精神分裂症组EBPM任务替换分[2(0,8)vs.1(0,8),P0.05]和TBPM任务漏报分[2(0,8)vs.0(0,6),P0.01]高于对照组;此外,精神分裂症组TBPM回顾性再认分也明显低于对照组[7(0,7)vs.7(5,7),P0.01]。结论:老年精神分裂症患者EBPM和TBPM均存在明显受损,受损阶段可能主要是自我启动的线索觉察与意图提取。此外,TBPM可能还在意图保持阶段有受损。
[Abstract]:Objective: to investigate the stage of event-based prospective memory (EBPM) and time-based prospective memory (TBPM) in elderly schizophrenics. Methods: Forty-one inpatients with senile schizophrenia in accordance with the fourth edition of the American Diagnostic and Statistical Manual for Mental Disorders and 55 normal controls with matched ages and educational attainment were selected. A prospective memory laboratory model was developed to evaluate the total score and internal scores of EBPM. The psychiatric and negative symptoms of patients were evaluated by (BPRS) and (BNSS). Continuous attention test (CPT) was used to evaluate the discrimination of signal / noise, and Wisconsin Card sorting Test (WCST) and semantic fluency (CF) (CF) were used to evaluate the executive function of the subjects, and the number of complete classification and correct response were recorded respectively. Results: the scores of EBPM [4 (0 8) vs.6 (0 8) P 0.01] and TBPM [2 (0 8) vs.6 (0 0 8) P 0 01] in schizophrenia group were lower than those in control group, the task replacement score of EBPM [2 (0 8) vs.1 (0 8) P 0 05] in schizophrenia group and the missing score of TBPM task [2 (0 8) vs.0 (0 0 6) P 0. 01] were significantly lower in schizophrenia group than those in control group [7 (0 7) vs.7 (57) P 0. 01]. In addition, the retrospective recognition score of TBPM in schizophrenia group was significantly lower than that in control group [7 (0 7) vs.7 (57) P 0. 01]. Conclusion: both EBPM and TBPM were significantly damaged in senile schizophrenic patients, and the main damage stage was self-priming cues and intention extraction. In addition, TBPM may also be damaged during the maintenance phase.
【作者单位】：北京大学北京回龙观医院;
【基金】：首都医学发展科研基金项目(计算机认知矫正治疗对老年轻度认知障碍的干预研究,2009-1056) 北京市卫生系统高层次卫生技术人才培养计划(神经免疫自由基,2011-3-077)
【分类号】：R749.3

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