阿尔兹海默病中线粒体损伤机制及多酚对其防治的研究进展

发布时间：2018-08-31 12:40

【摘要】：线粒体损伤是阿尔兹海默病(Alzheimer’s disease,AD)早期的突出特点,AD发生时线粒体的功能、形态、分布、诱导的凋亡机制均发生了明显改变。多酚类化合物因其具有强的抗氧化活性而表现出了对AD的防治作用。本文通过查阅2006-2016年的中英文文献(数据库包括中国知网、万方数据库、维普资讯、Pubmed,Science Direct及Springer),以"Alzheimer’s disease/AD/aging and mitochondria and polyphenol"的中英文关键词为检索策略,对AD病理过程中线粒体损伤机制和多酚类化合物对其防治作用,包括多酚类化合物对AD中线粒体能量代谢障碍、Bcl-2家族-线粒体凋亡途径诱导细胞凋亡、线粒体分裂融合紊乱及轴突运输损伤的保护机制研究进展做一综述。
[Abstract]:Mitochondrial damage is a prominent feature in the early stage of Alzheimer's disease (Alzheimer's disease,AD). The function, morphology, distribution and mechanism of apoptosis induced by AD have been significantly changed. Polyphenols exhibit a protective effect on AD because of their strong antioxidant activity. This paper refers to the Chinese and English literature from 2006 to 2016 (databases including China Zhiwang, Wanfang database, Weip information publish Science Direct and Springer),) using the Chinese and English keywords of "Alzheimer's disease/AD/aging and mitochondria and polyphenol" as the retrieval strategy. The mechanism of mitochondrial damage in AD and the protective effect of polyphenols on it, including the apoptosis induced by Bcl-2 family and mitochondrial apoptosis pathway, were induced by polyphenols on mitochondrial energy metabolism disorders in AD. The research progress of mitochondrial fission fusion disorder and axonal transport injury is reviewed.
【作者单位】：山西医科大学公共卫生学院营养与食品卫生学教研室;
【基金】：国家自然科学基金(No.81472984,81001245) 2013年度山西医科大学科技创新基金(No.01201301)
【分类号】：R749.16

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