成人正常海马结构断面的MRI测量

发布时间：2018-09-08 07:17

【摘要】：目的：本研究通过在MRI上测定成人正常海马结构特定层面的面积，确立一种参考标准，为群体性筛选和早期诊断癫痫及Alzheimer’s病提供新的思路。方法：分性别、年龄段选取90例成人正常海马结构断面的MRI扫描图像，分别在特定层面（冠状面、横断面和矢状面）上进行了同层面海马面积和大脑面积的测量，同时测量了冠状面海马纵轴相对于眦耳线的角度，并对其数据按性别、年龄进行相关统计分析。结果：海马冠状面、水平面和矢状面的左右侧面积比值的统计学分析，差异有显著性（P0.05）；但两性海马面积在进行了角度转换之后三个面上的差异均不具有显著性（P0.05）；大脑面积与海马面积的相关性亦不具有显著的统计学意义。结论：本研究证实了前人做出的大量研究工作，人体大脑左右侧海马存在差异，但也对海马标准化的正确性和两性差异上与其他学者的研究产生了分歧，，因而仍需进行更加深入的研究以证实其正确性。
[Abstract]:Objective: to establish a reference standard for early diagnosis of epilepsy and Alzheimer's 's disease by determining the area of normal hippocampal structure on MRI. Methods: the area of hippocampus and brain were measured on the coronal plane, cross section and sagittal plane of 90 adult normal hippocampal sections by MRI scanning images, which were divided into sex and age groups, and were measured on the coronal plane, cross section and sagittal plane, respectively. The angle of the coronal hippocampal longitudinal axis relative to the canthus ear line was measured, and the data were statistically analyzed by sex and age. Results: there was significant difference in the ratio of left and right side area between coronal plane, horizontal plane and sagittal plane of hippocampus (P0.05), but there was no significant difference in the area of hippocampus between the two sexes on the three sides after angle conversion (P0.05). There was no significant correlation between brain area and hippocampal area. Conclusion: this study confirms that there are differences in the left and right hippocampus of the human brain, but there are differences between the standardization of the hippocampus and the differences between the sexes and other scholars. Therefore, more in-depth research is needed to verify its correctness.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R742.1;R749.16

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