吕梁地区农村阿尔茨海默病及轻度认知障碍与同型半胱氨酸的关系
发布时间：2018-09-10 19:25
【摘要】：背景：随着世界人口的不断老龄化,痴呆正在成为一个全球性的公共卫生问题。阿尔茨海默病(Alzheimer's disease, AD)是一种进行性中枢神经系统的退行性疾病。临床表现为进行性记忆和认知障碍、言语障碍、精神运动异常等。轻度认知障碍(Mild cognitive impairment, MCI)是介于正常老化和痴呆或AD之间的临床过渡阶段,目前逐渐成为研究的热点。以往的研究中同型半胱氨酸(Homocysteine, Hcy)水平与老年痴呆症或MCI的相关性是有争议的,一些研究显示高Hcy会增加认知障碍的风险。进一步研究Hcy与AD及MCI的关系,对AD的预防及指导治疗有重要意义。 目的：探讨山西吕梁地区农村AD及MCI与Hcy的关系,以及与叶酸及维生素B12的关系,为AD的预防及指导治疗提供依据。 方法：通过对低叶酸地区山西吕梁农村3个镇55岁及以上6452个老年人的横断面调查,筛选出AD患者135例,MCI患者157例。采用病例对照研究的方法,选取资料全面及抽血的AD患者63名,MCI患者95名,按病例组的年龄、性别、地区、教育程度等互相匹配随机选出对照组90例,用荧光偏振免疫分析法(fluorescence polarization immunassay, FPIA)测出Hcy水平,用微粒子酶免分析法(microparticle enzyme immunoassay, MELA)测定叶酸及维生素B12水平。用统计学软件SPSS17.0进行统计分析。 结果：1.AD、MCI及对照组Hcy水平分别为26.6±19.94μmol/L、27.2±19.80μmol/L、19.7±14.42μmol/L,三组之间差异有统计学意义(p0.05)。AD组与对照组之间Hcy水平有统计学意义(p0.05),MCI组与对照组之间Hcy水平有统计学意义(p0.05),而AD组与MCI组之间差异无统计学意义(p0.05)。2.AD、MCI及对照组的叶酸值分别为10.0±10.97ng/mL、10.6±11.32ng/mL、11.4±11.81ng/mL,三组之间差异无统计学意义(p0.05),且组间差异均无统计学意义(p0.05)。AD、MCI及对照组的维生素B12值分别为157.31±91.10pg/mL、185.48±379.29pg/mL、195.2±389.25pg/mL,三组之间差异无统计学意义(p0.05),且组间差异均无统计学意义(p0.05)。 结论：1.吕梁地区农村AD及MCI患者的Hcy水平高于对照组；2.吕梁地区农村高Hcy水平可能为AD、MCI的危险因素；3.吕梁地区农村AD及MCI患者的叶酸及维生素B12水平可能并未显著低于对照组。
[Abstract]:Background: with the aging of the world population, dementia is becoming a global public health problem. Alzheimer's disease (Alzheimer's disease, AD) is a progressive degeneration of the central nervous system. The clinical manifestations were progressive memory and cognitive impairment, speech disorder, psychomotor disorder and so on. Mild cognitive impairment (Mild cognitive impairment, MCI) is a clinical transition between normal aging and dementia or AD. The association of homocysteine (Homocysteine, Hcy) levels with Alzheimer's disease or MCI has been controversial in previous studies, and some studies have shown that high Hcy increases the risk of cognitive impairment. Further study on the relationship between Hcy, AD and MCI is of great significance to the prevention and treatment of AD. Objective: to explore the relationship between AD, MCI and Hcy, folic acid and vitamin B12 in rural areas of Lv Liang, Shanxi Province, and to provide evidence for the prevention and treatment of AD. Methods: a cross-sectional survey of 6452 elderly people aged 55 years and above in 3 towns of Lv Liang in Shanxi Province in low folic acid area was carried out. One hundred and fifty-five patients with AD were selected. Using the method of case-control study, we selected 63 patients with AD with comprehensive data and 95 patients with AD. 90 cases of control group were randomly selected according to the matched age, sex, region and education level of the case group. The levels of Hcy and folic acid and vitamin B12 were measured by fluorescence polarization immunoassay (fluorescence polarization immunassay, FPIA) and microparticle enzyme immunoassay (microparticle enzyme immunoassay, MELA) respectively. Statistical software SPSS17.0 was used for statistical analysis. Results: 1. The Hcy levels of ADMCI and control group were 26.6 卤19.94 渭 mol/L,27.2 卤19.80 渭 mol/L,19.7 卤14.42 渭 mol/L, respectively. There were significant differences in Hcy level between AD group and control group (p0.05). Hcy level between AD group and MCI group was statistically significant (p0.05). There was no significant difference between the three groups (p0.05). 2. The folic acid values of the control group and the control group were 10.0 卤10.97ng / mLnL = 10.6 卤11.32ng / mL, 11.4 卤11.81ng / mL, respectively. There was no significant difference among the three groups (p0.05), and there was no significant difference between the three groups (p0.05). The values of vitamin B12 in the control group and the control group were 157.31 卤91.10pg / mLnL 185.48 卤379.29pgmL195.2 卤389.25pgmLrespectively, and there was no statistical difference between the three groups. There was no significant difference between the two groups (p 0.05). Conclusion 1. The level of Hcy in rural AD and MCI patients in Lv Liang area was higher than that in control group. High Hcy level may be the risk factor of AD,MCI in Lv Liang area. The levels of folic acid and vitamin B 12 in rural AD and MCI patients in Lv Liang area may not be significantly lower than those in control group.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R749.16
本文编号：2235391
[Abstract]:Background: with the aging of the world population, dementia is becoming a global public health problem. Alzheimer's disease (Alzheimer's disease, AD) is a progressive degeneration of the central nervous system. The clinical manifestations were progressive memory and cognitive impairment, speech disorder, psychomotor disorder and so on. Mild cognitive impairment (Mild cognitive impairment, MCI) is a clinical transition between normal aging and dementia or AD. The association of homocysteine (Homocysteine, Hcy) levels with Alzheimer's disease or MCI has been controversial in previous studies, and some studies have shown that high Hcy increases the risk of cognitive impairment. Further study on the relationship between Hcy, AD and MCI is of great significance to the prevention and treatment of AD. Objective: to explore the relationship between AD, MCI and Hcy, folic acid and vitamin B12 in rural areas of Lv Liang, Shanxi Province, and to provide evidence for the prevention and treatment of AD. Methods: a cross-sectional survey of 6452 elderly people aged 55 years and above in 3 towns of Lv Liang in Shanxi Province in low folic acid area was carried out. One hundred and fifty-five patients with AD were selected. Using the method of case-control study, we selected 63 patients with AD with comprehensive data and 95 patients with AD. 90 cases of control group were randomly selected according to the matched age, sex, region and education level of the case group. The levels of Hcy and folic acid and vitamin B12 were measured by fluorescence polarization immunoassay (fluorescence polarization immunassay, FPIA) and microparticle enzyme immunoassay (microparticle enzyme immunoassay, MELA) respectively. Statistical software SPSS17.0 was used for statistical analysis. Results: 1. The Hcy levels of ADMCI and control group were 26.6 卤19.94 渭 mol/L,27.2 卤19.80 渭 mol/L,19.7 卤14.42 渭 mol/L, respectively. There were significant differences in Hcy level between AD group and control group (p0.05). Hcy level between AD group and MCI group was statistically significant (p0.05). There was no significant difference between the three groups (p0.05). 2. The folic acid values of the control group and the control group were 10.0 卤10.97ng / mLnL = 10.6 卤11.32ng / mL, 11.4 卤11.81ng / mL, respectively. There was no significant difference among the three groups (p0.05), and there was no significant difference between the three groups (p0.05). The values of vitamin B12 in the control group and the control group were 157.31 卤91.10pg / mLnL 185.48 卤379.29pgmL195.2 卤389.25pgmLrespectively, and there was no statistical difference between the three groups. There was no significant difference between the two groups (p 0.05). Conclusion 1. The level of Hcy in rural AD and MCI patients in Lv Liang area was higher than that in control group. High Hcy level may be the risk factor of AD,MCI in Lv Liang area. The levels of folic acid and vitamin B 12 in rural AD and MCI patients in Lv Liang area may not be significantly lower than those in control group.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R749.16
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