LSP-39中文版在精神分裂症患者中的信效度分析及临床应用研究

发布时间：2018-09-13 21:48

【摘要】：目的：考察社会功能量表(Life Skill Profile-39, LSP-39)中文版在精神分裂症患者中的信度和效度以及临床应用的研究。方法：1.收集200例符合DSM-IV-TR精神分裂症诊断标准的门诊或住院精神分裂症患者,10例患者用于研究者一致性培训,200例进行个体和社会功能量表(Personal and Social Performance scale, PSP)、阳性和阴性症状量表(Positive and Negative Syndrome Scale, PANSS)和LSP-39中文版测评,分析LSP-39量表的内部一致性、LSP-39中文版与PSP的一致性(效标效度)以及与患者疾病严重度的相关性(关联效度)。25例患者在首次LSP-39中文版评估后的21天后,再次对患者进行第2次测评,评价LSP-39中文版的重测信度。2.采用LSP-39对296例住院及门诊的精神分裂症患者社会功能进行临床研究分析。结果：1.LSP-39中文版的内部一致性Cron-bachα系数为0.68-0.84,LSP-39中文版总分的研究者之间一致性Kappa值为0.61,重测一致性为0.92。LSP-39中文版总分与PSP有较好的相关性(ICC=0.88),与PANSS总分负相关(r=-0.37,P0.01)。 2.从非治疗因素看,文化程度高、婚姻稳定、社会支持好的患者社会功能好。从治疗因素看,治疗依从性好、近5年住院时间短、使用副反应小的新型抗精神病药物的患者社会功能较好。本研究发现门诊患者社会功能优于住院患者,此外,我们还发现患者社会功能与临床客观疗效判断变化趋势总体一致。结论：1.社会功能量表中文版是评估住院和门诊精神分裂症患者社会功能的一个简洁、易操作、较稳定的工具,适用于临床实践或研究中使用。2.要提高精神分裂症社会功能应当更多的考虑综合因素的作用,尤其强调早期干预、社会支持和药物、心理相结合的综合治疗。
[Abstract]:Objective: to investigate the reliability, validity and clinical application of the Chinese version of Social function scale (Life Skill Profile-39, LSP-39) in patients with schizophrenia. Method 1: 1. A total of 200 outpatient or inpatient schizophrenic patients who met the DSM-IV-TR criteria for schizophrenia diagnosis were collected for consistency training in 200 patients with individual and social function scale (Personal and Social Performance scale, PSP), positive and negative symptoms. The Chinese version of (Positive and Negative Syndrome Scale, PANSS) and LSP-39, To analyze the internal consistency of LSP-39 scale and the consistency between LSP-39 Chinese version and PSP, and the correlation between LSP-39 and patient disease severity (correlation validity). Twenty-five patients were evaluated 21 days after the first Chinese version of LSP-39. The patients were tested for the second time to evaluate the retest reliability of the Chinese version of LSP-39. LSP-39 was used to analyze the social function of 296 inpatients and outpatients with schizophrenia. Results 1. The internal consistency Cron-bach 伪 coefficient of the Chinese version of LSP-39 was 0.68-0.84 and the consistent Kappa value of the Chinese version of LSP-39 was 0.61.The retest consistency was that the total score of the Chinese version of 0.92.LSP-39 had a good correlation with PSP (ICC=0.88), and negatively correlated with the total score of PANSS (r-0.37, P0.01). In terms of non-therapeutic factors, patients with high education, stable marriage and good social support have good social function. According to the treatment factors, the patients with good treatment compliance, short hospital stay in the last 5 years and low side effects of new antipsychotics had better social function. In this study, we found that outpatients' social function was better than that of inpatients. In addition, we also found that the social function of outpatients was in accordance with the trend of objective clinical efficacy judgment. Conclusion 1. The Chinese version of the social function scale is a simple, easy to operate and stable tool for assessing the social function of inpatient and outpatient schizophrenic patients. It is suitable for clinical practice or research. In order to improve the social function of schizophrenia, more consideration should be given to the role of comprehensive factors, especially early intervention, social support and combined therapy with drugs and psychology.
【学位授予单位】：昆明医科大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R749.3

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