奥氮平联用利培酮对精神分裂症患者糖脂代谢的影响

发布时间：2018-10-05 08:48

【摘要】：目的探讨奥氮平与利培酮联用对精神分裂症患者糖脂代谢的影响。方法 90例老年精神分裂症患者随机均分为观察组与对照组,分别采用奥氮平与利培酮联用(观察组)和奥氮平单用(对照组)治疗;检测治疗前和治疗后6周空腹血糖(FBG)、糖化血红蛋白(HbA1c)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)和体质量(BM)。结果治疗后两组患者的精神症状均有明显的改善。观察组治疗前、后的FBG、HbA1C、TG、TC、HDL-C、LDL-C和BM均无统计学变化(P0.05);对照组患者治疗后FBG、TC、LDL-C和BM均较治疗前升高(P0.05)。两组患者治疗后比较显示,观察组患者的FBG、TG、TC、LDL-C和BM均低于对照组(P0.05)。结论与单独使用奥氮平相比,奥氮平联合利培酮治疗老年精神分裂症患者可以在不影响患者血糖、血脂及BM的前提下,改善患者的症状。
[Abstract]:Objective to investigate the effect of olanzapine combined with risperidone on glucose and lipid metabolism in schizophrenic patients. Methods 90 patients with senile schizophrenia were randomly divided into observation group and control group, which were treated with olanzapine combined with risperidone (observation group) and olanzapine alone (control group). Fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and body mass (BM). Were measured before and 6 weeks after treatment. Results after treatment, the mental symptoms of the two groups were significantly improved. Before and after treatment, the FBG,HbA1C,TG,TC,HDL-C,LDL-C and BM in the observation group were not significantly changed (P0.05); the FBG,TC,LDL-C and BM in the control group were higher than those before treatment (P0.05). After treatment, the FBG,TG,TC,LDL-C and BM of the two groups were lower than that of the control group (P0.05). Conclusion compared with olanzapine alone, olanzapine combined with risperidone can improve the symptoms of senile schizophrenia without affecting blood glucose, blood lipid and BM.
【作者单位】：新乡医学院第二附属医院(精神病医院)精神一科;
【分类号】：R749.3

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