精神分裂症患者攻击行为与炎症标志物的相关性
发布时间：2018-10-08 10:50
【摘要】：目的探讨炎症标志物与精神分裂症患者攻击行为的相关性。方法以精神分裂症患者为研究对象,所有患者均处于急性发作期。依据既往暴力史和修订版外显攻击行为量表(MOAS)加权总分区分攻击组(n=70)和非攻击组(n=40)。采用阳性与阴性症状量表(PANSS)评估临床症状,白细胞(WBC)、中性粒细胞(N)、C反应蛋白(CRP)、白细胞介素-6(IL-6)作为炎症标志物,比较两组临床症状与炎症标志物的差异,并对MOAS与PANSS总分、分量表评分及炎症标志物作相关分析。结果攻击组MOAS加权总分、言语攻击、对财产的攻击与体力攻击的评分均高于非攻击组,差异均有统计学意义(P0.01)。攻击组PANSS总分、阳性症状评分均高于非攻击组,差异均有统计学意义(P0.05)。两组WBC、N计数比较,差异无统计学意义(P0.05)。攻击组CRP、IL-6水平均高于非攻击组,差异均有统计学意义(P0.01)。MOAS加权总分与PANSS总分、阳性症状评分、一般精神病理评分、WBC计数、CRP及IL-6水平呈正相关(P0.05)。言语攻击与阳性症状评分、CRP及IL-6水平呈正相关(P0.05),与阴性症状评分呈负相关(P0.01)。对财产的攻击与WBC计数、CRP及IL-6水平呈正相关(P0.05)。自身攻击与一般精神病理评分,WBC、N计数,CRP及IL-6水平呈正相关(P0.05)。体力攻击与PANSS总分、阳性症状评分、一般精神病理评分、CRP及IL-6水平呈正相关(P0.05)。结论攻击组与非攻击组相比,攻击行为体现在言语攻击、对财产的攻击与体力攻击方面。PANSS总分、阳性症状评分、CRP及IL-6水平可能与精神分裂症患者攻击行为相关。WBC、N计数与精神分裂症患者攻击行为不相关。
[Abstract]:Objective to investigate the correlation between inflammatory markers and aggressive behavior in schizophrenic patients. Methods all the patients with schizophrenia were in acute attack. According to the past violence history and the revised explicit aggression behavior scale (MOAS) weighted total score, the group of aggression (nong 70) and the group of non aggression (n 40) were distinguished. The positive and negative symptom scale (PANSS) was used to evaluate the clinical symptoms, and the leukocyte (WBC), neutrophil (N) C-reactive protein (CRP), interleukin-6 (IL-6) was used as the inflammatory marker. The differences between the clinical symptoms and the inflammatory markers were compared between the two groups, and the total scores of MOAS and PANSS were compared. The score of subscale and inflammatory markers were analyzed. Results the scores of MOAS weighted total score, speech attack, property attack and physical attack in the attack group were higher than those in the non-attack group, and the difference was statistically significant (P0.01). The total score of PANSS and the score of positive symptoms in the attack group were higher than those in the non-attack group, and the difference was statistically significant (P0.05). There was no significant difference in WBC,N count between the two groups (P0.05). The level of CRP,IL-6 in attack group was higher than that in non-attack group, the difference was statistically significant (P0.01). The weighted total score of MOAS was positively correlated with total score of PANSS, positive symptom score, general psychopathology score and IL-6 level (P0.05). Verbal aggression was positively correlated with positive symptom score and IL-6 level (P0.05), and negatively correlated with negative symptom score (P0.01). The attack on property was positively correlated with WBC count and IL-6 level (P0.05). There was a positive correlation between self attack and general psychopathologic score, WBC C N count and IL-6 level (P 0.05). There was a positive correlation between physical aggression and total score of PANSS, positive symptom score, general psychopathology score and IL-6 level (P0.05). Conclusion compared with the non-attack group, the aggressive behavior of the attack group is the total score of speech attack, attack on property and physical attack, and the total score of PANSS. Positive symptom score and IL-6 level may not be related to aggressive behavior of schizophrenia patients. WBCU N count is not related to aggressive behavior of schizophrenic patients.
【作者单位】： 中山市第三人民医院早期干预科;
【基金】：中山市卫生局医学科研立项课题(编号:2013J149)
【分类号】：R749.3
[Abstract]:Objective to investigate the correlation between inflammatory markers and aggressive behavior in schizophrenic patients. Methods all the patients with schizophrenia were in acute attack. According to the past violence history and the revised explicit aggression behavior scale (MOAS) weighted total score, the group of aggression (nong 70) and the group of non aggression (n 40) were distinguished. The positive and negative symptom scale (PANSS) was used to evaluate the clinical symptoms, and the leukocyte (WBC), neutrophil (N) C-reactive protein (CRP), interleukin-6 (IL-6) was used as the inflammatory marker. The differences between the clinical symptoms and the inflammatory markers were compared between the two groups, and the total scores of MOAS and PANSS were compared. The score of subscale and inflammatory markers were analyzed. Results the scores of MOAS weighted total score, speech attack, property attack and physical attack in the attack group were higher than those in the non-attack group, and the difference was statistically significant (P0.01). The total score of PANSS and the score of positive symptoms in the attack group were higher than those in the non-attack group, and the difference was statistically significant (P0.05). There was no significant difference in WBC,N count between the two groups (P0.05). The level of CRP,IL-6 in attack group was higher than that in non-attack group, the difference was statistically significant (P0.01). The weighted total score of MOAS was positively correlated with total score of PANSS, positive symptom score, general psychopathology score and IL-6 level (P0.05). Verbal aggression was positively correlated with positive symptom score and IL-6 level (P0.05), and negatively correlated with negative symptom score (P0.01). The attack on property was positively correlated with WBC count and IL-6 level (P0.05). There was a positive correlation between self attack and general psychopathologic score, WBC C N count and IL-6 level (P 0.05). There was a positive correlation between physical aggression and total score of PANSS, positive symptom score, general psychopathology score and IL-6 level (P0.05). Conclusion compared with the non-attack group, the aggressive behavior of the attack group is the total score of speech attack, attack on property and physical attack, and the total score of PANSS. Positive symptom score and IL-6 level may not be related to aggressive behavior of schizophrenia patients. WBCU N count is not related to aggressive behavior of schizophrenic patients.
【作者单位】： 中山市第三人民医院早期干预科;
【基金】：中山市卫生局医学科研立项课题(编号:2013J149)
【分类号】：R749.3
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