学龄早期注意缺陷多动障碍儿童事件相关电位和行为问题的相关性

发布时间：2018-10-19 16:15

【摘要】：目的采用事件相关电位(ERP)技术和Achenbach儿童行为量表(CBCL)研究学龄早期注意缺陷多动障碍(ADHD)儿童的认知特征,探讨ERP与儿童行为问题的相关性。方法 22例6~7岁ADHD患儿和年龄匹配的19例正常儿童纳入研究。ERP试验采用持续性操作测试(CPT-AX)任务,对Go和Nogo的N2、P3成分进行波幅和潜伏期的比较分析。CBCL量表由患儿家长填写,分析行为因子与ERP成分的相关性。结果 ADHD组ERP遗漏数明显高于正常对照组(10±8 vs 5±4,P0.05),而两组反应时间和虚报数比较差异无统计学意义(P0.05)。ADHD组ERP的Go-N2波幅明显低于正常对照组(-8±5μV vs-10±4μV,P0.05)。ADHD组多动、攻击问题检出率均为27%,违纪问题检出率为9%。攻击及违纪因子得分与ERP的Go-N2波幅呈负相关(分别r=-0.43、r=-0.48,均P0.05),多动因子得分与Go-P3潜伏期呈正相关(r=0.50,P0.05)。结论学龄早期ADHD儿童已出现注意执行功能受损趋势,但抑制功能缺陷尚不明显。学龄早期ADHD儿童多动、攻击及违纪问题与ERP相关。
[Abstract]:Objective to study the cognitive characteristics of (ADHD) children with early school age attention deficit hyperactivity disorder (ADHD) by means of event-related potential (ERP) technique and Achenbach Child behavior scale (CBCL), and to explore the correlation between ERP and children's behavioral problems. Methods 22 patients with ADHD aged 6 to 7 years and 19 normal children with age matched were included in the study. The amplitude and latency of N2P 3 in Go and Nogo were compared and analyzed by using CPT-AX task in ERP test. The CBCL scale was filled out by the parents of the children. The correlation between behavioral factors and ERP components was analyzed. Results the number of ERP omissions in the ADHD group was significantly higher than that in the normal control group (10 卤8 vs 5 卤4 P 0.05), but there was no significant difference between the two groups in response time and false report (P0.05). The Go-N2 amplitude of ERP in the). ADHD group was significantly lower than that in the normal control group (-8 卤5 渭 V vs-10 卤4 渭 V P 0.05). ADHD). The detection rate of attack problem was 27%, and that of violation of discipline problem was 9%. The scores of attack and discipline violation factors were negatively correlated with the amplitude of Go-N2 in ERP (r = 0.43, P < 0.05, respectively), and the scores of hyperactivity factors were positively correlated with the latency of Go-P3 (r = 0.50, P 0.05). Conclusion the attention executive function is impaired in children with ADHD in early school age, but the inhibition function deficiency is not obvious. Hyperactivity, aggression and violation of discipline in early school age ADHD children were associated with ERP.
【作者单位】：南通大学附属常州市儿童医院;
【基金】：江苏省科技专项(BL2014037)
【分类号】：R749.94

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