精神分裂症和强迫障碍患者的全脑灰质体积及静息态脑功能局部一致性

发布时间：2018-10-21 16:31

【摘要】：目的:应用磁共振成像(MRI)技术探讨精神分裂症和强迫障碍(OCD)患者大脑灰质体积及静息态脑功能局部一致性(ReHo)的特征性表现。方法:选取符合精神障碍诊断与统计手册第4版(DSM-IV)诊断标准的22例精神分裂症患者、20例OCD患者及23例性别、年龄、受教育程度匹配的正常对照。所有研究对象先后完成高分辨率结构磁共振成像及静息态功能磁共振成像扫描,在全脑范围内基于体素分析精神分裂症和OCD患者灰质体积及ReHo的异常改变,同时探索精神分裂症和OCD共同的脑结构和功能异常特征。结果:精神分裂症与OCD共同表现为,前扣带回灰质体积低于正常对照(蒙特利尔神经科学研究所坐标(P0.001,未校正),左侧楔叶ReHo值比正常对照低(P0.001,未校正),左侧内侧额上回ReHo值比正常对照高(P0.001,未校正)。结论:精神分裂症和OCD患者具有共同的脑结构和功能异常特征,该改变一定程度上可作为两种疾病临床相似之处的解释。
[Abstract]:Objective: to investigate the characteristic features of (ReHo) in cerebral gray matter volume and resting brain function in patients with schizophrenia and obsessive-compulsive disorder (OCD) by magnetic resonance imaging (MRI). Methods: 22 schizophrenic patients, 20 OCD patients and 23 normal controls matched by sex, age and education were selected from 22 schizophrenic patients in accordance with the diagnostic criteria of the fourth edition (DSM-IV) of the Diagnostic and Statistical Manual for Mental Disorders (DSM-IV). All subjects completed high-resolution structural magnetic resonance imaging and resting functional magnetic resonance imaging respectively. The abnormal changes of gray matter volume and ReHo in patients with schizophrenia and OCD were analyzed based on voxel throughout the brain. At the same time, we explored the common abnormal features of brain structure and function between schizophrenia and OCD. Results: the common manifestations of schizophrenia and OCD were, The volume of gray matter in the anterior cingulate gyrus was lower than that in the normal control (P 0.001, uncorrected), the ReHo value of the left cuneiform lobe was lower than that of the normal control (P0.001, uncorrected), and the ReHo value of the left medial superior frontal gyrus was higher than that of the normal control (P0.001, uncorrected). Conclusion: schizophrenia and OCD have the same characteristics of abnormal brain structure and function, which can be used as an explanation for the clinical similarities between the two diseases.
【作者单位】：北京大学第六医院北京大学精神卫生研究所国家精神心理疾病临床医学研究中心(北京大学第六医院) 卫生部精神卫生学重点实验室(北京大学);
【基金】：国家自然科学基金资助项目国际(地区)合作与交流项目(81361120395),国家自然科学基金资助项目(81370032)
【分类号】：R749.3

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