抗精神病药对精神分裂症患者骨转换生化指标的影响

发布时间：2018-10-25 13:10

【摘要】：目的探讨奥氮平和利培酮对精神分裂症患者骨钙素和β胶原特殊序列水平的变化及其可能的相关因素。方法收集我院门诊/病房的年龄18~40岁精神分裂症患者90例,其中服用奥氮平的患者45例,服用利培酮的患者45例;收集健康人45例作为对照。收集患者一般人口学资料,采集患者清晨空腹静脉血5 ml,检测催乳素(PRL)、总胆固醇(CHOL)、甘油三酯(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、血糖(GLU)、胰岛素(INS)、雌二醇(E2)、睾酮、骨钙素(BGP)和β胶原特殊序列(β-CROSSL)。结果 (1)与正常对照组相比,奥氮平组和利培酮组患者BGP和β-CROSSL水平明显升高,且差异具有统计学意义(P0.05);但奥氮平组和利培酮组间BGP和β-CROSSL水平差异无统计学意义(P0.05)。(2)服药组的用药时间、LDL和GLU与BGP成负相关,INS和睾酮与BGP成正相关;药物和服药时间与β-CROSSL成正相关,LDL、GLU和E2与β-CROSSL成负相关。结论长期服药精神分裂症患者出现的糖脂代谢异常可能是导致骨质疏松出现的危险因素之一。
[Abstract]:Objective to investigate the effects of olanzapine and risperidone on the levels of osteocalcin and 尾 collagen in schizophrenic patients. Methods 90 schizophrenic patients aged 1840 years in outpatient / ward of our hospital were collected, including 45 patients with olanzapine and 45 patients with risperidone, and 45 healthy persons as control. The general demographic data of the patients were collected. Fasting venous blood samples were collected to detect prolactin, (PRL), total cholesterol, (CHOL), triglyceride, low density lipoprotein, (LDL), high density lipoprotein, (HDL), blood glucose, (GLU), insulin, (INS), estradiol (E _ 2) and testosterone. Osteocalcin (BGP) and 尾 Collagen specific sequences (尾-CROSSL).) Results (1) the levels of BGP and 尾-CROSSL in olanzapine group and risperidone group were significantly higher than those in normal control group. The difference was statistically significant (P0.05), but there was no significant difference in the levels of BGP and 尾-CROSSL between olanzapine group and risperidone group (P0.05). (2). LDL and GLU were negatively correlated with BGP, INS and testosterone were positively correlated with BGP. Drug and time were positively correlated with 尾-CROSSL, LDL,GLU and E2 were negatively correlated with 尾-CROSSL. Conclusion the abnormal metabolism of glucose and lipid may be one of the risk factors for osteoporosis.
【作者单位】：中南大学湘雅二医院精神病学科;中南大学湘雅二医院精神卫生研究所国家精神心理疾病临床医学研究中心精神疾病诊治技术国家地方联合工程实验室精神病学与精神卫生学湖南省重点实验室;
【基金】：湖南省科技厅重点项目(2012FJ086)
【分类号】：R749.3

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