慢性轻度不可预见性应激大鼠血液组分中17种氧化应激相关元素的测定分析

发布时间：2018-10-29 09:33

【摘要】：目的研究慢性轻度不可预见性应激(CUMS)对大鼠血浆和红细胞中17种氧化应激有关化学元素含量及分布的影响。方法 40只大鼠随机分为应激组和对照组,应激组使用CUMS方法处理28 d后测定其血浆、红细胞中17种化学元素的含量,分析元素间相关性。结果应激组血浆钼、硼元素及红细胞硒元素浓度高于对照组(P0.05);血浆锡、铬、钍、铊元素及红细胞锰、铅元素浓度低于对照组(P0.05)。元素间相关强度及方向改变:血浆钍-铁在对照组负相关(r=-0.581,P=0.018),在应激组正相关(r=0.473,P=0.035);血浆钍-镁在对照组负相关(r=-0.610,P=0.012),在应激组正相关(r=0.596,P=0.006)。结论 CUMS改变大鼠血浆及红细胞中多种氧化应激相关元素的含量及元素间相关性分布,并且含量升高的元素均为抗氧化应激元素,降低的元素多为促氧化应激元素。
[Abstract]:Objective to study the effects of chronic mild unpredictable stress (CUMS) on the contents and distribution of 17 chemical elements related to oxidative stress in plasma and erythrocytes of rats. Methods Forty rats were randomly divided into stress group and control group. After 28 days of treatment with CUMS method, the contents of 17 chemical elements in plasma and erythrocyte were measured in the stress group, and the correlation between them was analyzed. Results the concentrations of plasma molybdenum, boron and erythrocyte selenium in stress group were higher than those in control group (P0.05), and the concentrations of tin, chromium, thorium, thallium, erythrocyte manganese and lead in stress group were lower than those in control group (P0.05). The change of correlation intensity and direction between elements: the plasma thorium-iron was negatively correlated in the control group (r = 0.581P ~ (0.018) and positively in the stress group (r ~ (0.473N) P ~ (0.035). There was a negative correlation between plasma thorium and magnesium in the control group (r = 0.610) and a positive correlation in the stress group (r = 0.596P ~ 0. 006). Conclusion CUMS can change the content and distribution of various elements related to oxidative stress in plasma and erythrocytes of rats.
【作者单位】：北京大学公共卫生学院;
【分类号】：R749

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