L型钙离子通道α1C亚基基因多态性与精神分裂症的Meta分析

发布时间：2018-10-29 22:10

【摘要】：目的:用Meta分析的方法综合评价L型钙离子通道α1C亚基基因(calcium channel,voltage-dependent,L type,alpha1C subunit gene,CACNA1C)多态性位点与精神分裂症(schizophrenia,SCZ)的关系,为SCZ的遗传背景提供询证医学证据。方法:通过计算机对PubMed、中国生物医学文献光盘数据库(CBMdisc)数据库进行检索(2000年1月至2013年11月)。根据纳入标准收集CACNA1C多态性位点与SCZ病例对照研究的国内外全文文献。应用RevMan 5.1软件对符合条件的研究结果进行Meta分析,包括异质性检验,OR值以及评估发表偏倚。结果:共5篇外文文献符合条件并纳入分析,累计精SCZ组3 555例,健康对照组19 566例。数据合并结果显示,CACNA1C多态性位点rs1006737A型基因与SCZ有关联。按种族分为高加索亚组和亚洲亚组进行分析,组内无显著异质性,G/A+A/A vs.G/G基因型合并OR=1.16(95%CI=1.03~1.31)和1.29(95%CI=1.10~1.52),总效应测定结果 Z=2.39、3.09(均P0.05)。结论:CACNA1C多态性位点rs1006737 A型基因与SCZ有明显关联,且与高加索人和亚洲人群SCZ易感性相关,携带A型基因可能增加SCZ的患病风险。
[Abstract]:Objective: to evaluate the relationship between L type calcium channel 伪 1C subunit (calcium channel,voltage-dependent,L type,alpha1C subunit gene,CACNA1C) polymorphism and schizophrenia (schizophrenia,SCZ) by Meta analysis. Provide probative medical evidence for the genetic background of SCZ. Methods: PubMed, (CBMdisc) database of Chinese biomedical literature was searched by computer (January 2000 to November 2013). According to the inclusion criteria, the full text of CACNA1C polymorphism locus and SCZ case-control study were collected at home and abroad. RevMan 5.1 software was used for Meta analysis of eligible results, including heterogeneity test, OR value and evaluation of publication bias. Results: a total of 5 foreign literatures were included in the analysis. There were 3 555 cases in the SCZ group and 19 566 cases in the healthy control group. The results of data association showed that the rs1006737A type gene of CACNA1C polymorphism was associated with SCZ. There was no significant heterogeneity between Caucasian subgroup and Asian subgroup according to race. The G / A / A vs.G/G genotype combined with OR=1.16 (95%CI=1.03~1.31) and OR=1.16 (95%CI=1.10~1.52). The result of total effect was 2.39 ~ 3.09 (P 0.05). Conclusion: rs1006737 A gene in CACNA1C polymorphism is associated with SCZ, and is associated with SCZ susceptibility in Caucasians and Asian population. Carrying type A gene may increase the risk of SCZ.
【作者单位】：重庆医科大学神经科学研究中心;
【基金】：国家重大科学研究计划资助项目(编号:2009CB918300)
【分类号】：R749.3

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