基于稳定的ICA成分探究精神分裂症异常的功能脑区

发布时间：2018-11-02 18:28

【摘要】：目的:探讨精神分裂症患者显著异常的脑区。方法:对34例正常人对照组和41例精神分裂症患者进行静息状态下的功能磁共振扫描,采用独立成分分析以及其稳定成分的选取相结合来确定具有功能意义的成分,进行正常人与精神分裂症患者之间的双样本t检验。结果:找到6个可靠性高的独立成分,并筛选出一个具有功能研究意义的成分;确定精神分裂症患者和正常人之间存在功能异常的脑区,即信号减弱的脑区:左侧额中回(MFG)、左侧颞下回(ITG)、左侧眶部额上回(ORBsup)、左侧前扣带和旁扣带脑回(ACG)、右侧前扣带和旁扣带脑回(ACG)和左侧内侧前额叶(MPFC)。结论:发现除了ACG的双侧区域皆存在功能异常外,MFG、ITG、ORBsup、MPFC都是只有左侧存在功能异常,说明临床治疗精神分裂症患者时不可忽视脑区不对称性的影响;其次,研究发现功能异常的区域主要集中在前额叶,可能与记忆和自我控制能力的下降相关。
[Abstract]:Objective: to investigate the abnormal brain regions in schizophrenic patients. Methods: functional magnetic resonance imaging (fMRI) was performed in 34 normal controls and 41 schizophrenic patients at rest. Independent component analysis (ICA) and the selection of stable components were used to determine the functional components. Double-sample t-test was performed between normal and schizophrenic patients. Results: six independent components with high reliability were found and one component with functional significance was screened out. Identify areas of the brain with abnormal function between schizophrenic patients and normal people, that is, areas where the signal is attenuated: left middle frontal gyrus (MFG), left inferior temporal gyrus (ITG), left superior frontal gyrus (ORBsup), Left anterior cingulate and accessory cingulate gyrus (ACG), right anterior and accessory cingulate gyrus (ACG) and left medial prefrontal lobe (MPFC). Conclusion: with the exception of the bilateral regions of ACG, only the left side of MFG,ITG,ORBsup,MPFC has abnormal function, indicating that the effect of asymmetry in the brain region should not be ignored in the treatment of schizophrenia. Secondly, the study found that the dysfunctional regions are mainly located in the prefrontal lobe, which may be related to the decline of memory and self-control.
【作者单位】：郑州大学物理工程学院;中国科学院高能物理研究所核技术应用研究中心;北京市射线成像技术与装备工程技术研究中心;中南大学湘雅二医院精神卫生研究所;
【基金】：国家自然科学基金(81201147)
【分类号】：R749.3

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