首发抑郁症患者的静息态功能成像

发布时间：2018-11-10 17:46

【摘要】：目的运用REHO技术探讨首发抑郁症患者静息态脑功能的变化。方法采用GE 3.0T磁共振成像仪对18例首发抑郁症患者和20例性别、年龄相匹配的正常志愿者进行静息态功能成像(fMRI)检查,排除全脑器质性病变,运用DPARSF、REST分析软件进行全脑分析。结果抑郁症患者与正常志愿者比较,抑郁症患者存在多个与认知及情绪控制相关脑区的自发神经活动异常,其中在左侧后扣带回、双侧颞下回、双侧颞上回、左侧到岛盖部额下回、左侧海马、左侧中央后回、左侧角回、右侧杏仁核、右侧眶内额上回、右侧补充运动区、右侧小脑后叶局部一致性减低(P0.05)。结论首发抑郁症患者静息态脑功能存在部分脑功能异常。这些脑区均与认知和情绪的控制密切相关。
[Abstract]:Objective to investigate the changes of resting brain function in patients with first-episode depression by REHO technique. Methods 18 patients with first-episode depression and 20 normal volunteers with sex and age matched by GE 3.0T magnetic resonance imaging were examined by resting functional imaging (fMRI) to exclude the organic lesions of the whole brain. DPARSF, was used. REST software was used to analyze the whole brain. Results compared with normal volunteers, depression patients had abnormal spontaneous nerve activity in cognitive and emotional control related brain regions, including left posterior cingulate gyrus, bilateral infratemporal gyrus, bilateral superior temporal gyrus, and left posterior cingulate gyrus, bilateral inferior temporal gyrus and bilateral superior temporal gyrus. Left to subfrontal gyrus, left hippocampus, left central gyrus, left angular gyrus, right amygdaloid nucleus, right orbital superior frontal gyrus, right supplementary motor area, right posterior cerebellar lobe local consistency decreased (P0.05). Conclusion there are some abnormal brain functions in patients with first-episode depression. These brain regions are closely related to cognitive and emotional control.
【作者单位】：广东省人民医院放射科;广东省精神卫生研究中心;广东省省人民医院;
【基金】：国家自然科学基金(81171329) 广东省自然科学基金(S2011010005858)~~
【分类号】：R749.4;R445.2

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