新疆维吾尔族精神分裂症生物学样本数据库的建立

发布时间：2018-11-14 09:00

【摘要】：目的：收集并建立新疆维吾尔族及其他少数民族精神分裂症的临床资料及基因组DNA数据库，，分析新疆维吾尔族及其他少数民族精神分裂症患者初次入院病人与多次反复入院病人的文化程度、职业、遗传等方面的影响以及两组病人主要临床表现的差异及预后评估。方法：收集新疆维吾尔族及其他少数民族住院病人的一般临床资料并登记入“精神疾病家系调查表”，抽取外周静脉血，提取基因组DNA并存入新疆医科大学一附院重大疾病资源标本库保存。以住院次数将病人分为初次入院及反复入院两组，并运用PANSS和BPRS量表对其进行评定及分析。结果：新疆维吾尔族及其他少数民族精神分裂症多次入院与初次入院的患者中文化程度与职业p＜0.05，存在统计学差异；新疆少数民族精神分裂症两组病人BPRS评分与PANSS评分中，两量表总分、BPRS的缺乏活力因子中、PANSS的阳性症状与阴性症状量表中均p＜0.05，得分有统计学差异。而PANSS量表一般精神病理量表，BPRS焦虑抑郁、思维障碍、激活性及敌对性四个因子中p＞0.05，提示得分没有统计学意义，其临床表现可能基本相同。结论：新疆维吾尔族及其他少数民族精神分裂症的患者存有遗传倾向性；初次入院与多次反复入院的患者的文化程度及职业有明显差异，两组患者的主要临床表现也有明显的差别，这对其预后及用药方面有重大意义。
[Abstract]:Objective: to collect and establish the clinical data and genomic DNA database of schizophrenia of Uygur and other ethnic minorities in Xinjiang. To analyze the influence of education, occupation and heredity on the first admission and repeated admission of patients with schizophrenia of Uygur nationality and other ethnic minorities in Xinjiang, and the difference of main clinical manifestations and prognosis between the two groups. Methods: the general clinical data of inpatients of Uygur nationality and other ethnic minorities in Xinjiang were collected and registered in the Family questionnaire of Mental Disorders, and peripheral venous blood was extracted. Genomic DNA was extracted and stored in the resource library of major diseases in the first affiliated Hospital of Xinjiang Medical University. The patients were divided into first admission group and recurrent admission group according to the number of hospitalization. The patients were assessed and analyzed by PANSS and BPRS. Results: in Xinjiang Uygur nationality and other ethnic minorities, there were significant differences in education level and occupation (p < 0.05). In the BPRS score and PANSS score of Xinjiang minority schizophrenia patients, the total score of the two scales, the lack of vitality factor of BPRS, the positive symptoms of PANSS and the negative symptom scale were all P < 0.05, and there was statistical difference between the two scales (p < 0.05). But the general psychopathological scale of PANSS, BPRS anxiety and depression, mental disorder, activation and hostility of the four factors (p > 0.05) suggested that the score was not statistically significant, and its clinical manifestations may be basically the same. Conclusion: the patients with schizophrenia in Xinjiang Uygur nationality and other minority nationalities have genetic tendency. There were significant differences in education level and occupation between the first admission group and the repeated admission group, and there were significant differences in the main clinical manifestations between the two groups, which was of great significance to the prognosis and medication.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R749.3;TP311.13

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