高血压共病抑郁障碍患者执行功能特点研究

发布时间：2018-11-17 08:30

【摘要】：目的探讨高血压共病抑郁障碍患者的执行功能损害特点。方法将2013年1月至11月在北京大学精神卫生研究所门诊和住院患者分为4组,研究组为高血压共病抑郁40例,按性别、年龄、受教育程度匹配疾病对照组(包括高血压组35例,抑郁组32例)及健康对照组47例。所有受试者接受威斯康星卡片分类、Stroop色词干扰、连线测验、词语流畅性等神经心理学测验评估执行功能。结果威斯康星卡片分类测验中,高血压共病抑郁组的持续错误数明显多于高血压组、抑郁组和健康对照组(P0.05),完成分类数在各组中最少,与健康对照组比较差异有统计学意义(P0.05);Stroop色词干扰测验中,共病组Stroop-C的完成时间在各组中最长(P0.05),正确数少于抑郁组和健康对照组(P0.05),共病组Stroop-CW的正确数少于高血压组和健康对照组(P0.05);词语流畅性测验中,共病组产生词汇量少于健康对照组(P0.05);连线测验中,共病组的完成时间最长,错误数最多,但与对照组差异无统计学意义。结论高血压共病抑郁患者存在执行功能损害,其损害程度较抑郁障碍及高血压患者更明显。
[Abstract]:Objective to investigate the characteristics of executive function impairment in patients with depressive disorder of hypertension syndromes. Methods from January to November, 2013, outpatients and inpatients of Institute of Mental Health of Peking University were divided into 4 groups. The study group consisted of 40 patients with hypertension and depression. The patients in the control group were matched by sex, age and education level (including 35 patients in the hypertension group). Depression group (n = 32) and healthy control group (n = 47). All subjects were evaluated for executive function by Wisconsin card sorting, Stroop color word interference, line test, word fluency and other neuropsychological tests. Results in Wisconsin card sorting test, the number of persistent errors in depression group was significantly higher than that in hypertension group, depression group and healthy control group (P0.05). Compared with the healthy control group, the difference was statistically significant (P0.05). In the Stroop color word interference test, the complete time of Stroop-C was the longest (P0.05), the correct number was less than that of the depression group and the healthy control group (P0.05). The correct number of Stroop-CW in the co-disease group was less than that in the hypertension group and the healthy control group (P0.05). In the verbal fluency test, the vocabulary produced in the co-disease group was less than that in the healthy control group (P0.05); in the wired test, the completion time was the longest and the number of errors was the most in the co-disease group, but there was no significant difference between the co-disease group and the control group. Conclusion the degree of executive dysfunction in patients with hypertension and depression is more obvious than that in patients with depressive disorder and hypertension.
【作者单位】：北京大学精神卫生研究所;无锡市精神卫生中心;
【基金】：科技部国家科技支撑计划(2009BAI77B0)
【分类号】：R544.1;R749.4

【相似文献】