抗抑郁剂单药与联合用药治疗惊恐障碍的疗效及卫生经济学比较

发布时间：2018-11-22 06:20

【摘要】：目的：比较抗抑郁剂单药与联合使用非典型抗精神病药物治疗惊恐障碍的疗效及卫生经济学指标，为今后制定合理的治疗方案，降低医疗费用提供参考依据。方法：回顾性分析98例首次住院确诊的惊恐障碍患者的临床资料，，其中单独使用抗抑郁剂组（单药组）43例，联合使用非典型抗精神病药物（联合组）55例，两组患者均进行汉密顿焦虑量表（HAMA）、汉密顿抑郁量表（HAMD）评分。比较两组的治愈率、有效率、HAMA总分及各因子分、HAMD总分及各因子分、住院天数、住院费用等。结果：（1）单药组治愈率为67.4%，有效率97.7%，联合用药组治愈为63.6%，有效率98.2%，两组比较差异均无统计学意义（P＞0.05）。（2）两组患者治疗后HAMA总分、躯体化焦虑因子分及精神性焦虑因子分比较，差异均无统计学意义（P＞0.05）。（3）两组患者治疗后阻滞因子分比较，差异有统计学意义（P＜0.05）；但HAMD总分、焦虑/躯体化因子分、体重因子分、认识障碍因子分、睡眠障碍因子分、绝望感因子分及全身症状因子分比较，差异均无统计学意义（P＞0.05）。（4）两组住院天数比较差异无统计学意义（P＞0.05），但联合组住院费用高于单药组（P＜0.05）。结论：联合使用非典型抗精神病药物和单药治疗惊恐障碍，疗效无明显差异，患者住院天数未能减少，反而增加了住院费用。
[Abstract]:Objective: to compare the efficacy of antidepressant alone and atypical antipsychotics in the treatment of panic disorder and to provide reference basis for formulating reasonable treatment plan and reducing medical cost in the future. Methods: the clinical data of 98 patients with panic disorder diagnosed for the first time in hospital were retrospectively analyzed. There were 43 patients in the single antidepressant group and 55 in the combined group who were treated with atypical antipsychotics. Hamilton anxiety scale (HAMA),) and Hamilton Depression scale (HAMD) were used in both groups. The cure rate, effective rate, HAMA total score and each factor score, HAMD total score and each factor score, hospitalization days, hospitalization expenses and so on were compared between the two groups. Results: (1) the cure rate was 67.4 and the effective rate was 97.7in the single drug group, the cure rate was 63.6 in the combined group and the effective rate was 98.2. There was no significant difference between the two groups (P > 0.05). (2) there was no significant difference in the total score of HAMA, the score of somatization anxiety factor and the score of mental anxiety factor between the two groups after treatment (P > 0. 05). (3) there was significant difference in the scores of block factors between the two groups after treatment (P < 0.05). However, there was no significant difference in total HAMD score, anxiety / somatization factor score, body weight factor score, cognition disorder factor score, sleep disturbance factor score, despair factor score and systemic symptom factor score (P > 0. 05). (4) there was no significant difference in hospitalization days between the two groups (P > 0.05), but the cost of hospitalization in the combined group was higher than that in the single drug group (P < 0.05). Conclusion: the combination of atypical antipsychotics and single drug in the treatment of panic disorder has no significant difference in curative effect, and the hospitalization days of the patients are not reduced, but the hospitalization costs are increased.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R749.7

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