血管性痴呆患者性别、严重程度与血浆同型半胱氨酸、C反应蛋白、D-二聚体、生活方式的相关性

发布时间：2018-11-27 15:17

【摘要】：目的探讨血管性痴呆(VD)患者性别、严重程度与血浆同型半胱氨酸(Hcy)、C反应蛋白(CRP)、D-二聚体、生活方式的相关性。方法 VD患者443例采用自制调查量表对一般临床资料、生活方式等进行统计;利用简易精神状态检查表(MMSE)进行不同病情程度的分组,并检测Hcy、CRP及D-二聚体水平。结果不同病情程度间VD患者的Hcy、CRP、D-二聚体水平差异显著(P0.05),程度越重,Hcy、D-二聚体水平越高,CRP水平越低;单因素分析显示,不同年龄、性别、职业间VD的分布比例差异显著(P0.05);不同生活方式中,社会活动、每年旅游、棋牌、食用不饱和脂肪酸、使用鱼类及海产品、使用蔬菜等对患者发生VD的影响较大;多元Logistic回归显示,高龄、女性、家庭妇女是VD发病的危险因素,社会活动、每年旅游、棋牌、食用不饱和脂肪酸、使用鱼类及海产品、使用蔬菜等是VD发病的保护因素。结论改善高Hcy血症,检测血清CRP等炎症反应标志物及D-二聚体对VD的鉴别诊断具有一定参考意义;养成良好的生活方式有助于改善VD患者病情并延缓病程。
[Abstract]:Objective to investigate the relationship between sex, severity and plasma homocysteine (Hcy), C reactive protein (CRP), D dimer and lifestyle in patients with vascular dementia (VD). Methods A total of 443 patients with VD were investigated with self-made investigation scale for general clinical data and lifestyle, and Hcy,CRP and D-dimer levels were detected by simple mental state examination (MMSE). Results the level of Hcy,CRP,D- dimer in patients with VD was significantly different among different degree of disease (P0.05). The more serious the level of Hcy,D- dimer, the higher the level of Hcy,D- dimer and the lower the level of CRP. Univariate analysis showed that there were significant differences in the distribution of VD among different age, sex and occupation (P0.05). In different lifestyle, social activities, annual travel, chess cards, eating unsaturated fatty acids, using fish and seafood, using vegetables, etc., had a greater impact on the occurrence of VD. Multiple Logistic regression showed that old age, female and housewife were risk factors of VD, social activities, annual travel, chess and card, eating unsaturated fatty acids, using fish and seafood, using vegetables and so on were the protective factors of VD. Conclusion it is helpful for differential diagnosis of VD to improve hyperthermia, to detect serum CRP and D-dimer, and to develop a good lifestyle to improve the condition of VD patients and delay the course of disease.
【作者单位】：河南省人民医院神经内科;
【分类号】：R749.1

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