血管性认知障碍患者血清视黄醇结合蛋白水平与颈动脉粥样硬化斑块的相关性

发布时间：2018-11-28 20:27

【摘要】：目的探讨血管性认知障碍(VCI)患者颈动脉粥样硬化性斑块和视黄醇结合蛋白(RBP)含量的关系。方法选取93例VCI患者(VCI组)和93例正常对照者(对照组),检测血清RBP水平;同时检测VCI组、对照组患者血清尿酸(UA)和血浆D二聚体(DD)、纤维蛋白原(Fib)水平。对于VCI患者,结合其颈动脉超声检查结果,又分为无斑块组(40例)、颈动脉稳定斑块组(27例)、颈动脉不稳定斑块组(26例);测定并比较各组血清RBP水平。结果 VCI组血清RBP水平显著高于正常对照组(P0.05);在VCI患者中,颈动脉不稳定斑块组、稳定斑块组血清RBP水平也较无斑块组有明显升高(均P0.05),颈动脉不稳定斑块组血清RBP水平要显著高于稳定斑块组(P0.05);线性相关分析显示RBP水平与DD呈正相关(r=0.460,P0.05),与UA、Fib水平无相关性(r=0.095,0.139,均P0.05);Logistic回归分析结果显示:RBP是发生颈动脉粥样斑块的一个危险因素(OR=2.409,95%CI 0.351~0.719)。结论血清RBP可能是颈动脉粥样斑块的一个危险因素。它可能是VCI患者动脉粥样硬化不稳定斑块的一个生物学标志物。
[Abstract]:Objective to investigate the relationship between carotid atherosclerotic plaque and retinol binding protein (RBP) in patients with vascular cognitive impairment (VCI). Methods Serum RBP levels were measured in 93 patients with VCI (VCI group) and 93 normal controls (control group), and serum uric acid (UA) and plasma D-dimer (DD), fibrinogen (Fib) levels were detected in VCI group and control group. Patients with VCI were divided into 4 groups: no plaque group (40 cases), carotid artery stable plaque group (27 cases) and carotid unstable plaque group (26 cases). Results the level of serum RBP in VCI group was significantly higher than that in normal control group (P0.05). In VCI patients, the serum RBP level in the stable plaque group and the stable plaque group was significantly higher than that in the non-plaque group (P0.05), and the serum RBP level in the carotid artery unstable plaque group was significantly higher than that in the stable plaque group (P0.05). Linear correlation analysis showed that RBP level was positively correlated with DD (r = 0.460), but not with UA,Fib level (r = 0.095 卤0.139, all P 0.05). Logistic regression analysis showed that RBP was a risk factor for carotid atherosclerotic plaques (OR=2.409,95%CI 0.351 卤0.719). Conclusion Serum RBP may be a risk factor for carotid atherosclerotic plaque. It may be a biomarker of unstable atherosclerotic plaques in patients with VCI.
【作者单位】：南通大学第三附属医院无锡市第三人民医院神经内科;
【分类号】：R749.13

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