酒精依赖者脑功能改变的静息态fMRI研究及情绪记忆特点

发布时间：2018-12-07 15:37

【摘要】：目的采用静息态f MRI及行为学方法评价酒精依赖者静息态脑功能改变及情绪记忆特点。方法共纳入23例男性酒精依赖者,20例男性健康对照,采用E-prime软件编写程序,用联想笔记本电脑对所有受试者采集行为学数据,行为学结果采用单因素方差分析(one-way ANOVA)及多重比较分析。再通过3.0T MR仪器采集两组受试者的静息态功能磁共振数据,计算标准化f ALLF值和Re Ho值,并进行两独立样本t检验(two-sample t-test)比较其差异。结果1.酒精依赖组f ALFF值明显低于正常对照组(P0.001)的脑区包括:左侧额中回、左侧背外侧额上回、左侧中央前回、左侧中央后回、左侧中央旁小叶、左侧楔前叶、左侧顶上回及左侧顶下缘角回、右侧辅助运动区及右侧额中回。酒精依赖组f ALFF值明显高于正常对照组(P0.001)的脑区包括:右侧眶部额下回、右侧颞下回及右侧岛盖部额下回。2.酒精依赖组Re Ho值明显低于正常对照组(P0.001)的脑区包括:右侧眶部额下回、右侧眶部额中回、右侧中央后回及左侧眶部额叶内侧面。酒精依赖组Re Ho值明显高于正常对照组(P0.001)的脑区包括:右侧枕中回、右侧颞下回。3.酒精依赖组行为学成功采集16人,正常对照组行为学成功采集19人。结果发现,两组对恐惧图片和高兴图片的再认击中率明显高于中性图片,酒精依赖组与健康对照组对高兴图片的记忆效果无显著差异性(P=0.10),对恐惧图片、中性图片和伤心图片有显著差异性(P均0.05)。结论1.酒精依赖者静息态脑功能发生异常改变,主要累及到执行控制、感觉运动及情绪记忆等相关脑区,导致局部脑功能发生增强或减弱。2.酒精依赖者情绪记忆能力减退,对不同情绪图片的记忆结果有显著差异性,不同情绪图片的情绪记忆增强效应具有不同的调节机制。
[Abstract]:Objective to evaluate the changes of brain function and the characteristics of emotional memory in patients with alcohol dependence by resting f MRI and behavioral methods. Methods A total of 23 male alcohol-dependent subjects and 20 male healthy controls were included. The program was programmed with E-prime software and the behavioral data were collected from all subjects by associative notebook computer. The behavioral results were analyzed by single factor variance analysis (one-way ANOVA) and multiple comparative analysis. The resting fMRI data of the two groups were collected by 3.0T MR instrument, the normalized f ALLF and Re Ho values were calculated, and the difference was compared by two independent sample t-test (two-sample t-test). Result 1. In alcohol dependent group, the f ALFF values were significantly lower than those in the control group (P0. 001), including left middle frontal gyrus, left dorsolateral superior frontal gyrus, left precentral gyrus, left posterior central gyrus, left paracentral lobule, left precuneal lobe. Left superior parietal gyrus and left inferior parietal corner gyrus, right auxiliary motor area and right middle frontal gyrus. The value of f ALFF in alcohol dependent group was significantly higher than that in normal control group (P0. 001), including right inferior orbital gyrus, right infratemporal gyrus and right subfrontal gyrus of the right insular tegmental part. The Re Ho values of alcohol dependent group were significantly lower than that of normal control group (P0. 001), including right inferior orbitofrontal gyrus, right middle orbitofrontal gyrus, right posterior central gyrus and left medial orbital frontal lobe. The Re Ho values of alcohol dependent group were significantly higher than that of normal control group (P0. 001), including right middle occipital gyrus and right inferior temporal gyrus. The ethology of alcohol dependent group was successfully collected from 16 people, and that of normal control group was 19. The results showed that the recognition rate of fear picture and happy picture in the two groups was significantly higher than that in the neutral picture. There was no significant difference between the alcohol dependent group and the healthy control group in the memory effect of the happy picture (P0. 10). There was significant difference between neutral picture and sad picture (P 0.05). Conclusion 1. Abnormal changes of resting brain function occurred in alcohol-dependent patients, mainly involving executive control, sensorimotor, emotional memory and other related brain areas, resulting in the enhancement or weakening of local brain function. 2. The ability of emotional memory of alcohol-dependent patients was decreased, and the memory results of different emotional pictures were significantly different. The enhancement effect of emotional memory of different emotional pictures had different regulatory mechanisms.
【学位授予单位】：安徽医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R445.2;R749.62

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