强迫性用药行为的神经生物学机制研究进展

发布时间：2018-12-17 02:21

【摘要】：药物成瘾行为的核心特征是强迫性用药,即成瘾者对药物的寻求和摄取失控.药物成瘾行为的形成过程是由最初的目标导向性模式(A-O)向习惯化模式(S-R)的过渡,并最终发展为强迫性觅药和用药.成瘾行为形成过程的演变伴随腹侧纹状体(VS)到背侧纹状体(DS)多巴胺(DA)系统控制的转移;在DS中,中外侧纹状体(MLS)与长时程训练的觅药过程有关,而背外侧纹状体(DLS)则选择性参与强迫性觅药的调控.最新的研究还发现,长期用药导致的前额叶(PFC)功能的损害与强迫性行为的产生直接相关,且PFC不同亚区到纹状体的谷氨酸能投射对于觅药行为的调控存在竞争关系.此外,除了DA系统,五羟色胺(5-HT)系统对强迫性用药行为的形成也具有重要作用.本文将重点讨论成瘾相关的脑环路在强迫性觅药或用药过程中发挥的调控作用及其功能转换的潜在分子机制.
[Abstract]:The core characteristic of drug addiction behavior is compulsive drug use, that is, the drug seeking and ingestion of addicts is out of control. The forming process of drug addiction behavior is the transition from the initial goal-oriented model (A-O) to the habitual mode (S-R), and finally develops into compulsive drug seeking and drug use. The development of addictive behavior was accompanied by the transfer of (VS) from ventral striatum to (DS) dopamine (DA) system in dorsal striatum. In DS, (MLS) in the middle and lateral striatum is related to the drug seeking process during long term training, while (DLS) in the dorsolateral striatum selectively participates in the regulation of obsessive-compulsive drug seeking. Recent studies have also found that the impairment of (PFC) function in prefrontal lobe induced by long-term drug use is directly related to the production of obsessive-compulsive behavior, and that glutamate projections from different subregions of PFC to the striatum have a competitive effect on the regulation of drug seeking behavior. In addition to the DA system, the serotonin (5-HT) system also plays an important role in the formation of obsessive-compulsive drug use behavior. This paper will focus on the regulatory role of the brain loop associated with addiction in the process of compulsive drug seeking and its potential molecular mechanism of functional transformation.
【作者单位】：中国科学院心理研究所中国科学院心理健康重点实验室;中国科学院大学;
【基金】：国家自然科学基金(31170988);国家自然科学基金重大研究计划培育项目(91332115) 国家重点基础研究发展计划(2014CB553500) 中国博士后基金(2014M550869)资助
【分类号】：R749.61

【共引文献】