阻塞性睡眠呼吸暂停低通气综合征患者与抑郁的关系研究

发布时间：2018-12-21 17:21

【摘要】：第一部分阻塞性睡眠呼吸暂停低通气综合征患者与抑郁的关系研究目的研究阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者与抑郁症状的相关性。方法收集2014年1月-2015年10月来我院诊治的OSAHS患者96例为实验组,40例健康志愿者作为对照组,所有受试者均行多导睡眠(PSG)检测及Zung抑郁自评量表(SDS)检测,实验组根据睡眠呼吸紊乱指数(AHI)及最低血氧饱和度将患者分为轻度组(11例)、中度组(40例)和重度组(45例),比较各组之间抑郁症状的患病率。结果OSAHS组与对照组的体重指数、年龄差异无统计学意义,但OSAHS组的AHI数值、SDS评分明显高于对照组,而最低血氧饱和度(LSa02)则明显低于对照组。结论随着OSAHS患者病情的加重,抑郁的发病率逐渐增加。因此,早期诊断及治疗OSAHS有利于防止抑郁的发生。第二部分阻塞性睡眠呼吸暂停低通气综合征患者治疗前后抑郁症状的变化及干预对策目的观察研究阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者在术前、术后抑郁的发生和变化情况。方法收集2014年1月-2015年10月来我院诊治的中重度OSAHS的患者85例,所有患者均行UPPP手术,分别在手术前、术后3个月、术后半年对患者进行Zung抑郁自评量表(SDS)自我评价。结果OSAHS患者术前抑郁症状的发生率为54.1%,术后三个月抑郁症状的发生率有所降低,达到35.3%,术后六个月又进一步降低,但仍然有13%。SDS评分于术前、术后3月、术后半年依次递减,且术前与术后3月差异有统计学意义,术后3月与术后半年差异有统计学意义。结论OSAHS患者手术后抑郁症状明显改善,手术是缓解OSAHS患者打鼾等症状及抑郁症状的一种有效方式。临床医师应在术前对OSAHS患者存在的抑郁症状给予积极关注,尽量在术前就采取一定的干预措施,同时联合患者的家属及社会等方面对患者给予理解、关心和支持,以期减少术后抑郁症状的发生,提高手术疗效。
[Abstract]:Part one the relationship between obstructive sleep apnea hypopnea syndrome (OSAS) and depression objective to study the relationship between obstructive sleep apnea hypopnea syndrome (OSAHS) and depressive symptoms. Methods 96 OSAHS patients treated in our hospital from January 2014 to October 2015 were selected as experimental group and 40 healthy volunteers as control group. All subjects were tested with polysomnography (PSG) and Zung depression self-rating scale (SDS). Patients in the experimental group were divided into mild group (n = 11), moderate group (n = 40) and severe group (n = 45) according to sleep respiratory disorder index (AHI) and minimum oxygen saturation. Results there was no significant difference in body mass index and age between the OSAHS group and the control group, but the AHI value and SDS score in the OSAHS group were significantly higher than those in the control group, while the minimum oxygen saturation (LSa02) was significantly lower than that in the control group. Conclusion with the aggravation of OSAHS, the incidence of depression increases gradually. Therefore, early diagnosis and treatment of OSAHS is beneficial to prevent the occurrence of depression. The second part: changes of depressive symptoms and intervention measures in patients with obstructive sleep apnea hypopnea syndrome before and after treatment objective to investigate the changes of depression in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) before and after treatment. Occurrence and change of depression after operation. Methods from January 2014 to October 2015, 85 patients with moderate and severe OSAHS were treated in our hospital. All patients underwent UPPP operation. The patients were evaluated by (SDS) before operation, 3 months after operation and half a year after operation. Results the incidence of depressive symptoms in patients with OSAHS before operation was 54.1. The incidence of depressive symptoms decreased to 35.3in 3 months after operation, and decreased further six months after operation. However, there were still 13%.SDS scores before operation and 3 months after operation. Six months after operation decreased in turn, and there was significant difference between preoperative and postoperative three months, and three months after operation and six months after operation. Conclusion the depressive symptoms of patients with OSAHS were improved obviously, and surgery was an effective way to relieve the symptoms of snoring and depression in patients with OSAHS. The clinicians should pay active attention to the depressive symptoms of patients with OSAHS before operation, take some intervention measures as far as possible before the operation, at the same time, combine the family members of the patients and the society to give understanding, care and support to the patients. In order to reduce the incidence of postoperative depression symptoms and improve the effectiveness of surgery.
【学位授予单位】：郑州大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R766;R749.4

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