从谵妄的血清生物标志物探讨谵妄发生机制
发布时间：2018-12-25 14:59
【摘要】：谵妄是由多种影响因素引起大脑皮质功能障碍而发生的急性认知功能紊乱。目前关于谵妄病理生理机制的基础研究较少。谵妄生物标志物的研究有助于阐明其病理生理机制,且对其诊断、严重程度分级及远期结局预测有着重要意义。本文回顾了谵妄相关的三类血清生物标志物的研究进展:(1)风险标志物:谵妄发作前在血清中出现或增高表达,包括血清化学物、基因标志物等。(2)活性标志物:谵妄发生时增高表达,恢复时表达水平降低,包括乙酰胆碱、血清抗胆碱能活性、5-羟色胺、血清氨基酸、褪黑素、白细胞介素和C-反应蛋白等炎症标志物。(3)终产物:根据疾病的严重程度或结局呈比例升高,包括S-100?、神经元特异性烯醇酶等。以上三类标志物有助于我们进一步探讨谵妄的发生机制。
[Abstract]:Delirium is an acute cognitive disorder caused by multiple factors affecting cerebral cortex dysfunction. At present, there are few basic researches on the pathophysiological mechanism of delirium. The study of biomarkers of delirium is helpful to elucidate the pathophysiological mechanism of delirium and play an important role in the diagnosis, severity classification and long term outcome prediction. This paper reviews the research progress of three serum biomarkers associated with delirium: (1) risk markers: the presence or elevation of serum biomarkers, including serum chemicals, prior to the onset of delirium. (2) activity markers: increased expression at the onset of delirium and decreased expression at recovery, including acetylcholine, serum anticholinergic activity, serotonin, serum amino acid, melatonin, Inflammatory markers such as interleukin and C-reactive protein. (3) Endproduct: according to the severity or outcome of the disease increased proportionally, including S-100, neuron-specific enolase and so on. The above three kinds of markers are helpful to further study the pathogenesis of delirium.
【作者单位】： 四川大学华西医院国家老年疾病临床医学研究中心;四川大学华西医院老年医学中心;
【基金】：米尔斯坦基金(H1403014)
【分类号】：R749.1
本文编号：2391283
[Abstract]:Delirium is an acute cognitive disorder caused by multiple factors affecting cerebral cortex dysfunction. At present, there are few basic researches on the pathophysiological mechanism of delirium. The study of biomarkers of delirium is helpful to elucidate the pathophysiological mechanism of delirium and play an important role in the diagnosis, severity classification and long term outcome prediction. This paper reviews the research progress of three serum biomarkers associated with delirium: (1) risk markers: the presence or elevation of serum biomarkers, including serum chemicals, prior to the onset of delirium. (2) activity markers: increased expression at the onset of delirium and decreased expression at recovery, including acetylcholine, serum anticholinergic activity, serotonin, serum amino acid, melatonin, Inflammatory markers such as interleukin and C-reactive protein. (3) Endproduct: according to the severity or outcome of the disease increased proportionally, including S-100, neuron-specific enolase and so on. The above three kinds of markers are helpful to further study the pathogenesis of delirium.
【作者单位】： 四川大学华西医院国家老年疾病临床医学研究中心;四川大学华西医院老年医学中心;
【基金】：米尔斯坦基金(H1403014)
【分类号】：R749.1
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