银杏叶提取物片联合丁苯酞软胶囊对阿尔茨海默病的疗效及安全性观察

发布时间：2018-12-29 18:27

【摘要】：目的:观察银杏叶提取物片联合丁苯酞软胶囊对阿尔茨海默病的疗效及安全性。方法:将我院收治的80例阿尔茨海默病患者作为资料进行研究(纳入时间为2014年10月~2016年8月)。其中40例给予丁苯酞治疗(对照组),另外40例给予银杏叶提取物片联合丁苯酞软胶囊治疗(观察组)。分析两组治疗的疗效、相关量表进步情况、血清有关因子变化以及药物安全性。结果:治疗6个月后,观察组总有效率为82.50%,高于对照组60.00%(p0.05)。两组经治疗,MMSE、ADAS-cog和ADL得分均较治疗前进步(均p0.05);观察组以上三个量表得分分别为(20.38±1.17、31.19±0.97、27.94±1.15)分,均优于对照组(17.37±1.14、35.16±1.02、32.02±1.09)分(均p0.05)。两组经治疗,血浆NO和血清VEGF和MDA水平均优于治疗前(均p0.05);观察组以上三个指标水平分别为(44.07±1.04μmol/L、180.6±8.7ng/L、2.12±0.34μmol/L),均优于对照组(37.96±0.97μmol/L、169.4±8.2ng/L、3.28±0.38μmol/L)(均p0.05)。对照组在治疗期间出现15.00%的不良反应比例,高于观察组10.00%,但差异无统计学意义(p0.05)。结论:银杏叶提取物片能提高阿尔茨海默病的治疗效果,改善患者血清学相关指标,且不良反应少。
[Abstract]:Objective: to observe the efficacy and safety of ginkgo leaf extract tablet combined with butyphthalide soft capsule in the treatment of Alzheimer's disease. Methods: 80 patients with Alzheimer's disease were treated in our hospital as data (from October 2014 to August 2016). 40 cases were treated with butyphthalide (control group), the other 40 cases were treated with Ginkgo biloba extract tablet combined with butyphthalide soft capsule (observation group). To analyze the curative effect of the two groups, the progress of related scales, the changes of serum related factors and the safety of drugs. Results: after 6 months of treatment, the total effective rate of the observation group was 82.50, which was higher than that of the control group (60.00%, p0.05). After treatment, the scores of MMSE,ADAS-cog and ADL in both groups were improved compared with those before treatment (p0.05). The scores of the above three scales in the observation group were (20.38 卤1.17) 31.19 卤0.97 卤27.94 卤1.15, respectively, which were higher than those in the control group (17.37 卤1.14 卤35.16 卤1.02 卤1.09) (p0.05). The levels of plasma NO and serum VEGF and MDA in both groups were higher than those before treatment (all p0.05). The above three indexes in the observation group were (44.07 卤1.04 渭 mol/L,180.6 卤8.7 ng / L, 2.12 卤0.34 渭 mol/L), which were higher than those in the control group (37.96 卤0.97 渭 mol/L,169.4 卤8.2 ng / L). 3.28 卤0.38 渭 mol/L (all p0.05). The proportion of adverse reactions in the control group was 15.00%, which was higher than that in the observation group (10.00%), but the difference was not statistically significant (p0.05). Conclusion: Ginkgo biloba extract tablet can improve the therapeutic effect of Alzheimer's disease, improve the serological related indexes, and have less adverse reactions.
【作者单位】：海南医学院附属医院;
【分类号】：R749.16

【相似文献】