电针治疗创伤后应激障碍的功能磁共振研究

发布时间：2019-01-17 21:57

【摘要】：目的：以创伤后应激障碍患者为载体,功能磁共振成像为技术手段,分析在静息状态下电针治疗创伤后应激障碍患者脑区的局部一致性特点,探讨电针治疗创伤后应激障碍的中枢整合机制。方法：纳入12例创伤后应激障碍患者用电针治疗12周,对创伤后应激障碍患者治疗前、治疗6周后、治疗12周后使用临床监测量表、汉密尔顿抑郁量表、汉密尔顿焦虑量表进行评定。同时在电针治疗前后利用局部一致性方法检测静息状态下12例创伤后应激障碍患者的大脑局部一致性差异,评价治疗方案的临床疗效,并在此基础上分析针刺治疗创伤后应激障碍的中枢整合机制。结果：①该试验完成情况良好,电针治疗创伤后应激障碍疗效确切。临床监测量表、汉密尔顿抑郁量表、汉密尔顿焦虑量表评分治疗前后相比均有统计学意义(P0.05)。②与电针治疗前相比,在电针治疗后患者影像学显示左侧额中回、左侧颞上回、右侧额下回、右侧颞中回、右侧岛叶、右侧丘脑、扣带回、海马旁回、舌回、楔叶、前楔叶、尾状核、小脑等脑区局部一致性增高(P0.05,校正)。结论：电针治疗创伤后应激障碍患者具有一定效果,其有效机理可能与调节额叶、颞叶、岛叶、枕叶、边缘系统和小脑等脑区构成的神经环路有关。
[Abstract]:Objective: to analyze the characteristics of local consistency in the brain region of patients with post-traumatic stress disorder (PTSD) treated by electroacupuncture under resting condition, using functional magnetic resonance imaging (fMRI) as the carrier. To explore the central integration mechanism of electroacupuncture for post traumatic stress disorder (PTSD). Methods: twelve patients with post-traumatic stress disorder were treated with electroacupuncture for 12 weeks. The patients with post-traumatic stress disorder were treated with clinical monitoring scale and Hamilton depression scale before, after 6 weeks and 12 weeks after treatment. Hamilton anxiety scale was evaluated. At the same time, the local consistency of 12 patients with post-traumatic stress disorder (PTSD) was detected by local consistency method before and after electroacupuncture treatment, and the clinical effect of the treatment was evaluated. On this basis, the central integration mechanism of acupuncture for post-traumatic stress disorder was analyzed. Results: 1 the experiment was completed well and the effect of electroacupuncture on post-traumatic stress disorder was definite. The clinical monitoring scale, Hamilton depression scale and Hamilton anxiety scale score were statistically significant before and after treatment (P0.05). The local consistency of left superior temporal gyrus, right inferior frontal gyrus, right middle temporal gyrus, right insular lobe, right thalamus, cingulate gyrus, perihippocampal gyrus, lingual gyrus, cuneate lobe, anterior cuneate lobe, caudate nucleus and cerebellum were increased (P0.05, corrected). Conclusion: electroacupuncture is effective in the treatment of post-traumatic stress disorder, and its effective mechanism may be related to the regulation of neural loops in frontal lobe, temporal lobe, island lobe, occipital lobe, limbic system and cerebellum.
【学位授予单位】：成都中医药大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R749.5;R246.6

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