阿尔茨海默病伴发视觉障碍研究进展

发布时间：2019-02-12 13:05

【摘要】：阿尔茨海默病(AD)是老年人群常见的神经变性疾病,多以记忆力损害为首发症状,逐渐出现进行性认知功能受损和精神行为症状,对家庭和社会带来沉重的经济和照护负担。AD早期症状不明显,待诊断明确后的治疗效果差,因此,早期诊断尤为重要。研究发现,AD患者可出现视觉障碍,但尚无流行病学数据。目前AD的治疗包括非药物及药物等综合手段,AD伴发视觉障碍的治疗尚需研究。本文主要介绍AD视觉障碍的临床症状、发生机制、检测及评价手段,包括光学相干体层扫描、视觉诱发电位、视网膜微血管检查及神经影像学,以对AD患者的视觉障碍进行全面评价,寻找特异、敏感及简便的AD评估手段,为AD的早期诊断及早期干预提供依据。
[Abstract]:Alzheimer's disease (AD) is a common neurodegenerative disease in the elderly. Memory impairment is the first symptom, and progressive cognitive impairment and mental behavior symptoms appear gradually. It brings a heavy economic and care burden to family and society. The early symptoms of AD are not obvious and the effect of treatment after diagnosis is poor. Therefore, early diagnosis is particularly important. The study found that visual impairment can occur in patients with AD, but no epidemiological data are available. At present, the treatment of AD includes non-drug and drug therapy, and the treatment of AD with visual impairment still needs to be studied. This article mainly introduces the clinical symptoms, pathogenesis, detection and evaluation of AD visual disorders, including optical coherence tomography, visual evoked potential, retinal microvascular examination and neuroimaging. The purpose of this study was to evaluate the visual impairment of patients with AD, and to find a specific, sensitive and simple method for the evaluation of AD in order to provide evidence for early diagnosis and early intervention of AD.
【作者单位】：首都医科大学附属北京天坛医院神经病学中心;首都医科大学附属北京天坛医院国家神经系统疾病临床医学研究中心;首都医科大学教育部神经变性疾病重点实验室;北京脑重大疾病研究院;
【基金】：国家重点研发计划重点专项(2016YFC1306000,2016YFC1306300) 国家自然科学基金项目(81571229,81071015,30770745,81030062) 北京市自然科学基金项目(kz201610025030,4161004,kz200910025001,7082032) 国家重点基础研究发展计划(2011CB504100) 国家科技重大专项项目(2011ZX09102-003-01) 国家科技支撑计划项目(2013BAI09B03) 北京脑重大疾病研究院项目(BIBD-PXM2013_014226_07_000084) 北京市卫生系统高层次卫生技术人才培养计划项目(2009-3-26) 北京市属高等学校创新团队建设与教师职业发展计划项目(IDHT20140514) 首都临床特色应用研究(Z12110700100000,Z121107001012161) 北京市保健科研课题(京15-2,京15-3) 北京市优秀人才培养项目(20071D0300400076) 首都医科大学基础-临床科研合作基金项目(2015-JL-PT-X04,14JL5,10JL49) 首都医科大学附属北京天坛医院青年科研基金项目(2014-YQN-YS-18,2015-YQN-15,2015-YQN-05,2015-YQN-14,2015-YQN-17)
【分类号】：R749.16

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