解郁安神颗粒合盐酸帕罗西汀片治疗缺血性脑中风后抑郁症的临床分析
发布时间：2019-02-15 18:00
【摘要】：目的:探讨解郁安神颗粒合盐酸帕罗西汀片治疗缺血性脑中风后抑郁症的疗效以及对血清白细胞介素(IL)-6,IL-23,肿瘤坏死因子-α(TNF-α),去甲肾上腺素(NE)和5-羟色胺(5-HT)水平的影响。方法:筛选94例缺血性脑中风后抑郁症患者,按数字表法将所有病例随机分为观察组48例和对照组46例;两组患者根据《中国脑卒中康复治疗指南》给予常规治疗;对照组口服盐酸帕罗西汀片,初始剂量20 mg·d-1,每周以10 mg递增,最大剂量不超过40 mg·d-1。观察组在对照组治疗的基础上给予解郁安神颗粒,5 g/次,2次/d,冲服。两组患者均连续治疗6周。比较两组患者汉密尔顿抑郁(HAMD)量表评分,HAMD量表因子评分及临床疗效;检测两组患者血清IL-6,IL-23,TNF-α,NE和5-HT水平。结果:观察组治疗后3周和6周HAMD量表评分分别低于对照组同时点(P0.01);观察组治疗后HAMD量表各因子评分明显低于对照组(P0.01);观察组的临床总有效率为91.67%,高于对照组的71.74%(P0.05);治疗后观察组血清IL-6,IL-23和TNF-α水平均低于对照组,NE和5-HT水平均高于对照组,比较差异有统计学意义(P0.01)。结论:解郁安神颗粒合盐酸帕罗西汀片能提高缺血性脑中风后抑郁症的治疗,其治疗效果可能与下调患者血清IL-6,IL-23,TNF-α及上调NE,5-HT水平有关。
[Abstract]:Objective: to investigate the efficacy of Jieyu Anshen granule combined with paroxetine hydrochloride in the treatment of depression after ischemic stroke and the serum levels of interleukin (IL)-6 and tumor necrosis factor- 伪 (TNF- 伪). Effects of norepinephrine on the levels of (NE) and 5-hydroxytryptamine (5-HT). Methods: 94 patients with depression after ischemic stroke were randomly divided into observation group (n = 48) and control group (n = 46). In the control group, paroxetine hydrochloride tablets were given orally at an initial dose of 20 mg d ~ (-1), increasing at a weekly rate of 10 mg, with a maximum dose of less than 40 mg d ~ (-1). The observation group was treated with Jieyu Anshen granule, 5 g / time, 2 times / d, on the basis of treatment in the control group. The patients in both groups were treated continuously for 6 weeks. The scores of Hamilton depression (HAMD) scale, HAMD scale factor score and clinical efficacy were compared between the two groups, and the serum IL-6,IL-23,TNF- 伪, NE and 5-HT levels in the two groups were measured. Results: the scores of HAMD at 3 and 6 weeks after treatment in the observation group were lower than those in the control group (P0.01), and the scores of the factors of the HAMD scale in the observation group were significantly lower than those in the control group (P0.01). The total effective rate of the observation group was 91.67%, which was higher than that of the control group (71.74%) (P0.05). After treatment, the levels of serum IL-6,IL-23 and TNF- 伪 in the observation group were lower than those in the control group, and the levels of NE and 5-HT were higher than those in the control group (P0.01). Conclusion: Jieyu Anshen granule combined with paroxetine hydrochloride can improve the treatment of depression after ischemic stroke, and its therapeutic effect may be related to the down-regulation of serum IL-6,IL-23,TNF- 伪 and up-regulation of NE,5-HT level.
【作者单位】： 重庆市中医院;贵阳中医学院第二附属医院;
【基金】：贵州省中医药管理局中医药、民族医药科学技术课题(QZYY2011-29)
【分类号】：R743.3;R749.4
，
本文编号：2423594
[Abstract]:Objective: to investigate the efficacy of Jieyu Anshen granule combined with paroxetine hydrochloride in the treatment of depression after ischemic stroke and the serum levels of interleukin (IL)-6 and tumor necrosis factor- 伪 (TNF- 伪). Effects of norepinephrine on the levels of (NE) and 5-hydroxytryptamine (5-HT). Methods: 94 patients with depression after ischemic stroke were randomly divided into observation group (n = 48) and control group (n = 46). In the control group, paroxetine hydrochloride tablets were given orally at an initial dose of 20 mg d ~ (-1), increasing at a weekly rate of 10 mg, with a maximum dose of less than 40 mg d ~ (-1). The observation group was treated with Jieyu Anshen granule, 5 g / time, 2 times / d, on the basis of treatment in the control group. The patients in both groups were treated continuously for 6 weeks. The scores of Hamilton depression (HAMD) scale, HAMD scale factor score and clinical efficacy were compared between the two groups, and the serum IL-6,IL-23,TNF- 伪, NE and 5-HT levels in the two groups were measured. Results: the scores of HAMD at 3 and 6 weeks after treatment in the observation group were lower than those in the control group (P0.01), and the scores of the factors of the HAMD scale in the observation group were significantly lower than those in the control group (P0.01). The total effective rate of the observation group was 91.67%, which was higher than that of the control group (71.74%) (P0.05). After treatment, the levels of serum IL-6,IL-23 and TNF- 伪 in the observation group were lower than those in the control group, and the levels of NE and 5-HT were higher than those in the control group (P0.01). Conclusion: Jieyu Anshen granule combined with paroxetine hydrochloride can improve the treatment of depression after ischemic stroke, and its therapeutic effect may be related to the down-regulation of serum IL-6,IL-23,TNF- 伪 and up-regulation of NE,5-HT level.
【作者单位】： 重庆市中医院;贵阳中医学院第二附属医院;
【基金】：贵州省中医药管理局中医药、民族医药科学技术课题(QZYY2011-29)
【分类号】：R743.3;R749.4
，
本文编号：2423594
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