电针疗法对网瘾患者冲动行为及脑磁共振波谱（MRS）影响的研究
发布时间：2019-02-18 07:51
【摘要】：目的： 本研究拟运用电针疗法为干预手段,采用磁共振波谱(magnetic resonance spectroscopy, MRS)相关指标对互联网成瘾综合症(internet addiction disorder, IAD)产生的冲动行为机制做探讨,同时利用有关网瘾和冲动特质评价量表(barratt impulsivity scale-11, BIS-11)的评分,以及反应抑制功能测试任务(Go/No-go)的完成情况,来了解电针干预对冲动行为的影响,以期为未来相关研究提供更为科学客观的评价体系和全面的治疗方案。 方法： 将符合IAD纳入标准的32例受试者随机分成两组,每组16例,其中脱落2例、剔除1例,实际完成受试为29例。电针组15例,采取电针干预；心理组14例,采取认知行为疗法干预。分别治疗两个疗程。治疗前后采用网瘾自评量表、BIS-11冲动量表、Go/No-go任务以及磁共振波谱技术(MRS)的相关指标观察各组冲动行为心理状态、反应抑制及大脑生化代谢的变化。另招募正常志愿者16例,设为正常对照组,采集网瘾自评量表、BIS-11冲动量表、Go/No-go任务以及MRS相关指标对比,观察正常组与实验组治疗前后在心理状态、反应抑制及大脑生化代谢变化的差异。 结果： 1、网络瘾白评量表显示无论是电针还是心理行为康复疗法都对IAD患者网络成瘾症状、恶劣心境以及精神依赖等心理感受有明显的改善作用。组间比较差异说明电针在改善IAD心理或精神症状上效果更显著。 2、BIS-11的结果表明,无论哪种干预疗法,在改善IAD患者的冲动人格特质、降低冲动性上都是有效而显著的,但电针组在改善冲动特质的构成因素上范围更广,且比心理疗法更显著。 3、Go/No-go任务结果显示,行即时针刺后,正常组无论正确率(ACC)还是反应时间(RT)均表现出显著差异(P0.05),说明即时针刺的确可提高反应抑制的能力。实验组在治疗前行即时针刺,无论ACC还是RT改变均无显著差异(P0.05)；经过治疗后再对这两组网瘾受试者进行即时针刺,尽管完成Go/No-go任务的正确率(ACC)无显著变化(P0.05),但反应时间(RT)均显著缩短(P0.05),说明经过治疗后,网瘾患者与反应抑制和冲动控制相关的脑区功能得到改善,同时执行任务的神经通路反应敏感性增高,因此对即时针刺的反应比治疗前表现得更为敏感。 4、MRS结果显示电针后NAA/Cr的比值比治疗前升高,且差异显著(P0.05)；而心理组没有这样显著的改变,说明针刺对与冲动行为和反应抑制功能相关的脑区的生化代谢情况影响更明显,在两个疗程结束后可显著提高脑内NAA含量,从一定程度上反应了电针治疗具有更明显的脑保护作用。
[Abstract]:Objective: to explore the mechanism of impulsive behavior induced by internet addiction syndrome (internet addiction disorder, IAD) by magnetic resonance spectroscopy (magnetic resonance spectroscopy, MRS) and electroacupuncture therapy (EA). In order to understand the effect of electroacupuncture intervention on impulsive behavior, the scores of Internet addiction and impulsive trait assessment scale (barratt impulsivity scale-11, BIS-11) and the completion of response inhibition function test (Go/No-go) were also used to understand the effect of electroacupuncture intervention on impulsive behavior. In order to provide a more scientific and objective evaluation system and comprehensive treatment plan for future related research. Methods: 32 subjects who met the criteria of IAD were randomly divided into two groups: 16 cases in each group, 2 cases dropped out, 1 case was eliminated, 29 cases were actually completed. 15 cases in electroacupuncture group were treated with electroacupuncture intervention, and 14 cases in psychological group were treated with cognitive behavioral therapy. Two courses of treatment were given respectively. Before and after treatment, the mental state of impulsive behavior, inhibition of reaction and the changes of biochemical metabolism of brain were observed by using self-rating scale of Internet addiction, BIS-11 impulse scale, Go/No-go task and (MRS) of magnetic resonance spectroscopy. In addition, 16 normal volunteers were recruited as normal control group. The self-rating scale of Internet addiction, BIS-11 impulse scale, Go/No-go task and MRS related indexes were collected to observe the psychological status of normal group and experimental group before and after treatment. Differences in response inhibition and changes in brain biochemical metabolism. Results: 1. The results showed that both electroacupuncture and psycho-behavioral rehabilitation therapy could significantly improve the psychological feelings of IAD patients, such as internet addiction symptoms, bad mood and mental dependence. The difference between groups showed that electroacupuncture was more effective in improving psychological or mental symptoms of IAD. The results of BIS-11 showed that either intervention therapy was effective and significant in improving impulsive personality traits and reducing impulsivity in patients with IAD, but the electroacupuncture group had a wider range of factors in improving impulsive traits. And more significant than psychotherapy. 3The results of Go-No-go task showed that the correct rate of (ACC) and the response time (RT) of the normal group were significantly different after immediate acupuncture (P0.05), which indicated that the instant acupuncture could improve the ability of response inhibition. There was no significant difference in the changes of ACC and RT before treatment in the experimental group (P0.05). After treatment, both groups were treated with instant acupuncture. Although the correct rate of Go/No-go task had no significant change in (ACC) (P0.05), the reaction time (RT) was significantly shortened (P0.05). The results showed that after treatment, the function of brain area related to response inhibition and impulse control was improved, and the sensitivity of neural pathway to task was increased, so the response to immediate acupuncture was more sensitive than that before treatment. 4 the results of Mrs showed that the ratio of NAA/Cr after electroacupuncture was higher than that before treatment, and the difference was significant (P0.05). However, there was no significant change in psychological group, indicating that acupuncture had more obvious effect on biochemical metabolism of brain regions related to impulsive behavior and response inhibition function, and could significantly increase the content of NAA in brain after two courses of treatment. To a certain extent, electroacupuncture therapy has more obvious brain protection.
【学位授予单位】：成都中医药大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R454.1;R749.99
本文编号：2425632
[Abstract]:Objective: to explore the mechanism of impulsive behavior induced by internet addiction syndrome (internet addiction disorder, IAD) by magnetic resonance spectroscopy (magnetic resonance spectroscopy, MRS) and electroacupuncture therapy (EA). In order to understand the effect of electroacupuncture intervention on impulsive behavior, the scores of Internet addiction and impulsive trait assessment scale (barratt impulsivity scale-11, BIS-11) and the completion of response inhibition function test (Go/No-go) were also used to understand the effect of electroacupuncture intervention on impulsive behavior. In order to provide a more scientific and objective evaluation system and comprehensive treatment plan for future related research. Methods: 32 subjects who met the criteria of IAD were randomly divided into two groups: 16 cases in each group, 2 cases dropped out, 1 case was eliminated, 29 cases were actually completed. 15 cases in electroacupuncture group were treated with electroacupuncture intervention, and 14 cases in psychological group were treated with cognitive behavioral therapy. Two courses of treatment were given respectively. Before and after treatment, the mental state of impulsive behavior, inhibition of reaction and the changes of biochemical metabolism of brain were observed by using self-rating scale of Internet addiction, BIS-11 impulse scale, Go/No-go task and (MRS) of magnetic resonance spectroscopy. In addition, 16 normal volunteers were recruited as normal control group. The self-rating scale of Internet addiction, BIS-11 impulse scale, Go/No-go task and MRS related indexes were collected to observe the psychological status of normal group and experimental group before and after treatment. Differences in response inhibition and changes in brain biochemical metabolism. Results: 1. The results showed that both electroacupuncture and psycho-behavioral rehabilitation therapy could significantly improve the psychological feelings of IAD patients, such as internet addiction symptoms, bad mood and mental dependence. The difference between groups showed that electroacupuncture was more effective in improving psychological or mental symptoms of IAD. The results of BIS-11 showed that either intervention therapy was effective and significant in improving impulsive personality traits and reducing impulsivity in patients with IAD, but the electroacupuncture group had a wider range of factors in improving impulsive traits. And more significant than psychotherapy. 3The results of Go-No-go task showed that the correct rate of (ACC) and the response time (RT) of the normal group were significantly different after immediate acupuncture (P0.05), which indicated that the instant acupuncture could improve the ability of response inhibition. There was no significant difference in the changes of ACC and RT before treatment in the experimental group (P0.05). After treatment, both groups were treated with instant acupuncture. Although the correct rate of Go/No-go task had no significant change in (ACC) (P0.05), the reaction time (RT) was significantly shortened (P0.05). The results showed that after treatment, the function of brain area related to response inhibition and impulse control was improved, and the sensitivity of neural pathway to task was increased, so the response to immediate acupuncture was more sensitive than that before treatment. 4 the results of Mrs showed that the ratio of NAA/Cr after electroacupuncture was higher than that before treatment, and the difference was significant (P0.05). However, there was no significant change in psychological group, indicating that acupuncture had more obvious effect on biochemical metabolism of brain regions related to impulsive behavior and response inhibition function, and could significantly increase the content of NAA in brain after two courses of treatment. To a certain extent, electroacupuncture therapy has more obvious brain protection.
【学位授予单位】：成都中医药大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R454.1;R749.99
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