美沙酮维持治疗门诊受治者治疗依从性的病例对照研究

发布时间：2019-03-03 17:54

【摘要】：目的分析影响美沙酮维持治疗(MMT)依从性的因素。方法采用病例对照研究方法,以MMT依从性较差者为病例组,依从性较好者为对照组,应用复合性国际诊断访谈问卷(CIDI-3.0)、Beck抑郁问卷(BDI)、社会支持评定量表(SSRS)等,对昆明市9个MMT门诊符合条件的受治者进行调查。结果病例组156人,对照组270人。单因素分析显示,婚姻状况(P0.05)、职业情况(P0.05)、现住址居住时间(P0.05)、偷吸毒品(P0.05)为治疗依从性的影响因素。多因素非条件Logistic回归分析显示,无职业[比值比(OR)=2.610,95%可信区间(CI):1.378~3.983]、偷吸海洛因(OR=3.468,95%CI:2.084~5.769)、重度抑郁终身患病率(OR=4.276,95%CI:1.222~14.961),自我讨厌感:对自己丧失信心(OR=1.164,95%CI:1.066~2.817)、对自己失望(OR=1.882,95%CI:1.300~3.323),丧失兴趣:兴趣比以往减少(OR=1.709,95%CI:1.093~2.673)、丧失大部分兴趣(OR=2.895,95%CI:1.448~5.778)为治疗依从性差的危险因素。结论美沙酮维持治疗门诊治疗依从性好的受治者中,有自杀意念的比例较高,无职业、偷吸海洛因、重度抑郁终身患病率、自我讨厌感、丧失兴趣可能为治疗依从性的危险因素。
[Abstract]:Objective to analyze the factors influencing the compliance of methadone maintenance therapy for (MMT). Methods A case-control study was conducted. The patients with poor compliance with MMT and those with better compliance were selected as the control group. The CIDI-3.0), Beck Depression questionnaire (BDI),) was used. Social support rating scale (SSRS) was used to investigate 9 MMT outpatients in Kunming. Results there were 156 cases in the case group and 270 in the control group. Univariate analysis showed that marital status (P0.05), occupational status (P0.05), current residence time (P0.05), drug abuse (P0.05) were the influencing factors of treatment compliance. Multivariate non-conditional Logistic regression analysis showed that there was no occupation [odds ratio (OR) = 2.610, 95% confidence interval (CI): 1.378 / 3.983], heroin abuse (OR=3.468,95%CI:2.084~5.769), Life-long prevalence of severe depression (OR=4.276,95%CI:1.222~14.961), self-loathing: loss of confidence in yourself (OR=1.164,95%CI:1.066~2.817), disappointment in yourself (OR=1.882,95%CI:1.300~3.323), Loss of interest: less interest than ever (OR=1.709,95%CI:1.093~2.673), and loss of most interest (OR=2.895,95%CI:1.448~5.778) is a risk factor for poor treatment compliance. Conclusion among the patients with good compliance with methadone maintenance treatment, the proportion of patients with suicidal ideation is higher, no occupation, heroin abuse, severe depression lifetime prevalence, self-abomination, self-abomination. Loss of interest may be a risk factor for treatment compliance.
【作者单位】：云南省药物依赖防治研究所;昆明医科大学第一附属医院精神科;江苏省镇江市精神卫生中心;
【基金】：国家十二五科技重大专项“重点人群减少艾滋病新感染和死亡综合干预研究”(2012ZX10001-007)~~
【分类号】：R749.64

【相似文献】