快感缺乏的不同成分在精神分裂症谱系障碍中的受损特点

发布时间：2019-03-22 13:28

【摘要】：目的:探索快感缺乏的不同成分(消费性快感缺乏和抽象性消费快感)在精神分裂症谱系障碍(超高危、急性期和稳定期)中的严重程度和特点。方法:选取符合精神病风险综合征诊断标准的22例超高危患者(超高危组)、符合美国精神障碍诊断与统计手册第4版诊断标准的23例精神分裂症首次发病的急性期患者(急性期组)和18例精神分裂症稳定期患者(稳定期组),以及22例正常对照。采用阳性和阴性症状量表(PANSS)评价阳性症状严重程度、阴性症状量表(SANS)评价阴性症状严重程度、愉快情绪体验量表(TEPS)评价快感缺乏严重程度。采用ANOVA检验或非参数检验及其两组间差异的比较分析4组快感缺乏的特点,采用Pearson相关分析快感缺乏自评与他评之间的相关性。结果:超高危组、急性期组患者TEPS消费性快感缺乏得分[(37±9),(34±8)vs.(44±9),P0.01]和抽象性消费快感缺乏得分[(24±6),(21±7)vs.(28±6),P0.01]高于正常对照。稳定期组患者与正常对照的TEPS消费性快感缺乏得分和抽象性消费快感缺乏得分的差异无统计学意义(P0.05)。4组TEPS期待性快感缺乏得分差异无统计学意义(P0.05)。超高危组和急性期组中,TEPS消费性快感缺乏得分和期待性快感缺乏得分与SANS快感缺乏得分相关无统计学意义(P0.05)。稳定期组中,TEPS消费性快感缺乏得分和期待性快感缺乏得分与SANS快感缺乏得分高度负相关(r=-0.60~-0.80,均P0.05)。结论:急性期精神分裂症患者和超高危人群,而非稳定期患者,可能存在明显的消费性快感缺乏而非期待性快感缺乏。快感缺乏的自评和他评结果在急性期精神分裂症患者和超高危人群中可能缺乏一致性,而在稳定期患者中具有一致性。
[Abstract]:Aim: to explore the severity and characteristics of different components of pleasure deficiency (consumer pleasure deficiency and abstract consumption pleasure) in schizophrenia pedigree disorders (super-high risk, acute phase and stable phase). Methods: 22 super-high risk patients (ultra-high risk group) who met the diagnostic criteria of psychotic risk syndrome were selected. Twenty-three patients with first onset of schizophrenia (acute stage group) and 18 schizophrenic patients (stable phase group) who met the diagnostic criteria of the fourth edition of the American Handbook for diagnosis and Statistics of Mental Disorder were included in this study, as well as 22 normal controls. Positive and negative symptom scale (PANSS) was used to evaluate the severity of positive symptoms, negative symptom scale (SANS) was used to evaluate the severity of negative symptoms, and pleasure experience scale (TEPS) was used to evaluate the severity of lack of pleasure. ANOVA test or non-parametric test and the difference between the two groups were used to analyze the characteristics of the lack of pleasure in four groups, and the correlation between self-evaluation and other evaluation was analyzed by Pearson correlation analysis. Results: in the ultra-high risk group and the acute phase group, the TEPS consumption pleasure deficiency score [(37 卤9), (34 卤8) vs. (44 卤9), P0.01] and abstract consumption pleasure deficiency score [(24 卤6), (21 卤7) vs. (28 卤6)]. P0.01] higher than the normal control. There was no significant difference in the scores of TEPS consumer pleasure deficiency and abstract consumption pleasure deficiency between the stable group and the normal control group (P0.05). There was no significant difference in the TEPS expected pleasure deficiency score among the four groups (P0.05). In ultra-high risk group and acute stage group, there was no significant correlation between TEPS consumer pleasure deficiency score and expected pleasure deficiency score and SANS pleasure deficiency score (P0.05). In stable period group, the scores of TEPS consumer pleasure deficiency and expected pleasure deficiency were negatively correlated with SANS pleasure deficiency (r = 0.60 / 0.80, both P0.05). Conclusion: acute schizophrenia patients and super-high-risk population, but not stable patients, may have a significant lack of consumer pleasure rather than expectation of pleasure deficiency. [WT5 "HZ] conclusion:\? The results of self-assessment and other assessment with lack of pleasure may not be consistent in schizophrenic patients and super-high-risk population in acute phase, but they may be consistent in patients with stable phase.
【作者单位】：北京大学精神卫生研究所北京大学第六医院卫生部精神卫生学重点实验室(北京大学);北京大学人民医院;中国科学院心理研究所心理健康重点实验室神经心理学与应用认知神经科学实验室;
【基金】：北京市科委重点项目(D121100005012004)
【分类号】：R749.3

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