脑白质疏松伴轻度认知功能障碍患者的弥散张量成像研究

发布时间：2019-04-19 00:07

【摘要】：目的研究脑白质疏松(LA)伴有轻度认知功能障碍(MCI)患者的脑白质弥散张量成像(DTI),分析LA伴MCI患者早期脑白质微观结构的变化与临床表现之间的关系。方法选取LA伴MCI患者31例(病例组),另选健康体检者27例(对照组),2组行常规头颅MRI及DTI扫描,并进行认知及心理检查,最后采用基于纤维束的空间统计方法分析2组之间部分各向异性(FA)值的差异。结果与对照组比较,病例组右侧新纹状体、内囊前肢、额叶眶皮质及深部白质,左侧中央前回、中央旁小叶及深部白质区域的FA值明显下降,差异有统计学意义(P0.05)。结论 LA伴MCI患者的右侧新纹状体、内囊前肢、额叶眶皮质及深部白质,左侧中央前回、中央旁小叶及深部白质区域的白质纤维的完整性受到损害,且这些部位的损伤与患者的临床表现包括认知功能障碍、运动功能下降及泌尿功能障碍有关。
[Abstract]:Objective to investigate the relationship between the changes of white matter microstructure and clinical manifestations in patients with LA with MCI by diffusion Zhang Liang imaging (DTI), in patients with (LA) with mild cognitive impairment (MCI). Methods Thirty-one LA patients with MCI and 27 healthy subjects (control group) were selected. Routine head MRI and DTI scans were performed in the two groups, and cognitive and psychological examinations were performed in the two groups, and the patients were divided into two groups: control group (n = 27) and control group (n = 27). Finally, a spatial statistical method based on fiber bundle was used to analyze the difference of partial anisotropic (FA) values between the two groups. Results compared with the control group, the FA values of the right new striatum, anterior limb of the internal capsule, orbital cortex and deep white matter of frontal lobe, left anterior central gyrus, paracentric lobule and deep white matter were significantly decreased in the patient group (P0.05). Conclusion the integrity of the right new striatum, anterior limb of internal capsule, frontal orbital cortex and deep white matter, left anterior central gyrus, paracentric lobule and deep white matter in LA patients with MCI is impaired. These injuries were associated with cognitive dysfunction, motor dysfunction and urinary dysfunction.
【作者单位】：首都医科大学附属北京天坛医院神经内科;邯郸市中心医院神经内科;
【基金】：国家自然科学基金(81071115) 北京市卫生系统高层次卫生技术人才培养计划(2011-3-023)
【分类号】：R749.1

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