阿尔茨海默病治疗性单链抗体的研究进展
发布时间：2019-04-27 00:52
【摘要】：阿尔茨海默氏病(AD)的免疫治疗方法自提出以来尽管经历了些许挫折,但经过研究人员多年不懈努力,已经得到了快速发展。其中针对β-淀粉样蛋白的单链抗体(scFv)已经成为AD治疗性抗体中最有希望实现突破的一种策略,并正在成为免疫治疗AD的抗体药物研究的前沿和热点。本文概述了AD治疗性scFv的来源优势,对AD致病抗原识别与结合的特点,改善AD病理特征的效应以及与其效应相关的脑转运机制和体外亲和力成熟过程和结构因素,旨在为相关研究提供理论线索和发展思路。
[Abstract]:Although the immunotherapy for Alzheimer's disease (AD) has experienced some setbacks since it was put forward, it has been developed rapidly after years of unremitting efforts by researchers. Single chain antibody against 尾-amyloid protein (scFv) has become one of the most promising strategies to achieve breakthrough in therapeutic antibody of AD, and is becoming the frontier and hot spot in the research of antibody drugs in immunotherapy of AD. In this paper, the source advantages of AD therapeutic scFv, the characteristics of recognition and combination of AD pathogenic antigens, the effect of improving the pathological features of AD, the mechanism of brain transport related to the effect, and the process and structural factors of in vitro affinity maturation were reviewed. The purpose of this paper is to provide theoretical clues and development ideas for related research.
【作者单位】： 吉林大学分子酶学工程教育部重点实验室 生命科学学院;
【基金】：吉林省科技厅计划项目(20110956)
【分类号】：R749.16
[Abstract]:Although the immunotherapy for Alzheimer's disease (AD) has experienced some setbacks since it was put forward, it has been developed rapidly after years of unremitting efforts by researchers. Single chain antibody against 尾-amyloid protein (scFv) has become one of the most promising strategies to achieve breakthrough in therapeutic antibody of AD, and is becoming the frontier and hot spot in the research of antibody drugs in immunotherapy of AD. In this paper, the source advantages of AD therapeutic scFv, the characteristics of recognition and combination of AD pathogenic antigens, the effect of improving the pathological features of AD, the mechanism of brain transport related to the effect, and the process and structural factors of in vitro affinity maturation were reviewed. The purpose of this paper is to provide theoretical clues and development ideas for related research.
【作者单位】： 吉林大学分子酶学工程教育部重点实验室 生命科学学院;
【基金】：吉林省科技厅计划项目(20110956)
【分类号】：R749.16
【参考文献】
相关期刊论文 前1条
1 黄雪媚;李兴安;张应玖;;免疫治疗阿尔茨海默病的研究及其意义[J];中国神经免疫学和神经病学杂志;2008年05期
【共引文献】
相关期刊论文 前10条
1 陈燕珍;谭涛;杨栋林;刘洁雯;李谋岚;;木薯叶过氧化物酶的分离纯化及其同工酶的研究[J];安徽农业科学;2009年36期
2 王静;贾英民;;黑曲霉乳糖酶固定化前后酶学性质比较研究[J];安徽农业科学;2010年02期
3 郭会灿;;植酸酶催化活性的研究[J];安徽农业科学;2010年08期
4 刘晓晶;李田;翟增强;;纤维素酶的研究现状及应用前景[J];安徽农业科学;2011年04期
5 张东霞;王云普;曾家豫;张继;;HRP催化对苯二胺合成苯胺低聚物[J];宝鸡文理学院学报(自然科学版);2006年02期
6 杨雪梅,张兰英,张蕾,于宏兵,张玉玲;固定化酶在高浓度有机废水处理中的应用[J];吉林大学学报(地球科学版);2005年03期
7 马会强;张兰英;刘娜;刘虹;李爽;赵U，
本文编号：2466542
本文链接：https://www.wllwen.com/yixuelunwen/jsb/2466542.html
最近更新
教材专著
