~1H-MRS波谱成像与血管性非痴呆认知障碍的关系

发布时间：2019-04-30 05:55

【摘要】：目的:应用磁共振波谱(1 H-MRS)技术,探讨血管性非痴呆认知障碍(VCIND)患者的颅内物质代谢变化与认知障碍的关系。方法:对25例VCIND患者(A组)及23例脑梗死后认知功能正常(NCI,B组)进行简易精神状态检查量表(MMSE)和蒙特利尔认知评分量表(MoCA)评分,并对视空间及执行功能进行评分。根据认知功能评分结果,将两组患者进行1 H-MRS检查,测定双侧颞叶N-乙酰天冬氨酸(NAA)及胆碱复合物(Cho)与肌酸(Cr)比值,并探讨A、B两组物质代谢比值与MoCA评分、视空间及执行功能间的相关性。结果:与B组(NCI)NAA/Cr(左颞叶1.52±0.071、右颞叶1.51±0.06)相比,A组患者NAA/Cr(左颞叶1.37±0.08、右颞叶1.42±0.06)均下降(P0.05),A组颞叶NAA/Cr值下降程度与MoCA评分、视空间及执行功能评分呈正相关;A、B组间Cho/Cr比值变化无统计学意义。结论:1 H-MRS检测颞叶代谢物变化对VCIND的早期诊断有重要作用。
[Abstract]:Aim: to investigate the relationship between intracranial substance metabolism and cognitive impairment in patients with vascular non-dementia cognitive impairment (VCIND) by magnetic resonance spectroscopy (1-H-MRS). Methods: 25 patients with VCIND (group A) and 23 patients with normal cognitive function after cerebral infarction (NCI,B group) were assessed with (MMSE) and (MoCA). The visual space and executive function were evaluated. According to the results of cognitive function score, 1 H-MRS was performed in the two groups. The ratio of N-acetylaspartic acid (NAA) and choline complex (Cho) to creatine (Cr) in bilateral temporal lobe was measured. The correlation between the ratio of substance metabolism and MoCA score, visual space and executive function between group B and group B. Results: compared with group B (left temporal lobe 1.52 卤0.071, right temporal lobe 1.51 卤0.06), NAA/Cr (left temporal lobe 1.37 卤0.08, right temporal lobe 1.42 卤0.06) was significantly decreased in group A (P0.05), (NCI) NAA/Cr in group A was significantly lower than that in group B (1.52 卤0.071 in left temporal lobe and 1.51 卤0.006 in right temporal lobe). In group A, the decrease of NAA/ Cr in temporal lobe was positively correlated with MoCA score, visual space and executive function score. There was no significant difference in the ratio of Cho/Cr between groups A and B. Conclusion: 1Detection of temporal lobe metabolites by H-MRS plays an important role in the early diagnosis of VCIND.
【作者单位】：武汉脑科医院;
【基金】：武汉市卫生局基金资助项目(编号:WX12D22)
【分类号】：R749.1

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