老年广泛性脑萎缩患者并发认知功能障碍的临床特点研究

发布时间：2019-05-01 06:08

【摘要】：目的探讨老年广泛性脑萎缩患者并发认知功能障碍的临床特点,为随访观察提供参考。方法选择广泛性脑萎缩老年患者90例,根据有无痴呆分为痴呆组45例,正常组45例。测量体质量,询问17项慢性病史,并记录居住地区、受教育程度、职业、遗传病史、饮食等12项一般临床资料。检测血清白蛋白、丙氨酸转氨酶、血清肌酐、维生素B12、同型半胱氨酸等15项生化指标。结果正常组与痴呆组在性别、体质量指数、地区、受教育程度、职业、遗传病史、留置导尿等方面比较,差异无统计学意义(P0.05);痴呆组年龄≥80岁(73.3%vs 48.9%)、持续3个月服用8种以上口服药(28.9%vs 11.1%)、同时有5种以上慢性病(71.1%vs 44.4%)、脑出血(20.0%vs2.2%)、脑梗死(37.8%vs 17.8%)比例明显高于正常组(P0.05)。正常组与痴呆组在血红蛋白、血小板计数、丙氨酸转氨酶、天冬氨酸转氨酶、白蛋白、尿素、肌酐、尿酸、TC、TG、LDL-C、空腹血糖、叶酸、维生素B12、同型半胱氨酸等方面比较,差异无统计学意义(P0.05)。结论脑萎缩并发认知功能障碍患者有年龄≥80岁、持续3个月服用8种以上口服药、同时有5种以上慢性病等特点,这些特点将为脑萎缩患者随访中保护认知功能提供依据。
[Abstract]:Objective to investigate the clinical features of cognitive dysfunction in elderly patients with generalized cerebral atrophy and to provide reference for follow-up observation. Methods 90 elderly patients with generalized cerebral atrophy were divided into dementia group (n = 45) and normal group (n = 45). Body mass was measured, 17 items of chronic history were asked, and 12 items of general clinical data such as living area, education level, occupation, genetic history, diet and so on were recorded. Serum albumin, alanine transaminase, serum creatinine, vitamin B12 and homocysteine were measured. Results there was no significant difference in sex, body mass index, area, education level, occupation, genetic history and indwelling catheterization between normal group and dementia group (P0.05). The dementia group was more than 80 years old (73.3%vs 48.9%), took more than 8 oral drugs (28.9%vs 11.1%) for 3 months, and had 5 or more chronic diseases (71.1%vs 44.4%). The percentage of cerebral hemorrhage (20.0% vs 2.2%) and cerebral infarction (37.8%vs 17.8%) was significantly higher than that of normal group (P0.05). In normal group and dementia group, hemoglobin, platelet count, alanine transaminase, aspartate transaminase, albumin, urea, creatinine, uric acid, TC,TG,LDL-C, fasting blood glucose, folic acid, vitamin B12, Homocysteine and other aspects of comparison, the difference was not statistically significant (P0.05). Conclusion the patients with cerebral atrophy complicated with cognitive dysfunction have the characteristics of taking more than 8 oral drugs for 3 months and more than 5 kinds of chronic diseases. These characteristics will provide evidence for the protection of cognitive function in the follow-up of patients with cerebral atrophy.
【作者单位】：连云港市第二人民医院老年医学科;
【基金】：蚌埠医学院科研项目(Byky1289NF)
【分类号】：R749.1

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