国内抑郁症与白介素-6相关性的Meta分析

发布时间：2019-05-09 02:52

【摘要】：目的采用Meta分析的方法系统评价抑郁症与白介素-6(interleukin-6,IL-6)浓度之间的关联。方法计算机检索PubMed、中国生物医学文献数据库、维普中文期刊数据库、相关期刊论文和万方数据资源系统,收集中国人群抑郁症与IL-6相关性的病例对照研究,采用RevMan 5.2.8软件对IL-6浓度进行Meta分析。结果共纳入9项研究,包括432例抑郁症患者和277名对照。患者组IL-6浓度高于对照组(SMD=1.48,95%CI:0.78~2.18,P0.05)。亚组分析示,首发亚组和非首发亚组中,抑郁症患者IL-6浓度均高于对照组[首发亚组(SMD=1.94,95%CI:0.07~3.81,P0.05),非首发亚组(SMD=1.26,95%CI:0.60~1.93,P0.05)]。结论抑郁症与血清(血浆)中IL-6的浓度变化有关,但鉴于纳入研究的局限性,IL-6浓度与抑郁症发作性质和严重程度的定量相关性,本研究并未得到证实,尚需开展更多高质量、大样本的研究予以证实。
[Abstract]:Objective to evaluate the relationship between levels of interleukin-6 (interleukin-6,IL-6) and depression by Meta analysis. Methods PubMed, Chinese Biomedical Literature Database, Vip Chinese Journal Database, Chinese Journal full-text Database and Wanfang data Resource system were searched by computer. Case-control studies on the relationship between depression and IL-6 in Chinese population were collected. Meta analysis of IL-6 concentration was carried out by RevMan 5.2.8 software. Results A total of 9 studies were included, including 432 patients with depression and 227 controls. The concentration of IL-6 in the patient group was higher than that in the control group (SMD=1.48,95%CI:0.78~2.18,P0.05). Subgroup analysis showed that the concentration of IL-6 in the first subgroup and the non first subgroup was higher than that in the control group [first subgroup (SMD=1.94,95%CI:0.07~3.81,P0.05), non first subgroup (SMD=1.26,95%CI:0.60~1.93,)]. (P 0.05). Conclusion depression is related to the change of IL-6 concentration in serum (plasma). However, in view of the limitations of the study, the quantitative correlation between IL-6 concentration and the nature and severity of depression has not been confirmed in this study. More research on high quality and large samples is needed to confirm it.
【作者单位】：中国人民解放军成都军区总医院药剂科;成都军区司令部第三门诊部;
【分类号】：R749.4

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