注意缺陷多动障碍COMT基因多态性与哌甲酯疗效研究
发布时间：2019-05-24 11:35
【摘要】：目的探讨儿茶酚-O-甲基转移酶(catechol-O-Methyltransferase,COMT)基因多态性对注意缺陷多动障碍(attention deficit hyperactivity disorder,ADHD)儿童服用哌甲酯治疗效果的影响。方法对177例汉族ADHD患儿进行2~4周的哌甲酯开放剂量滴定,获得最佳治疗反应。在治疗前后使用ADHD诊断量表(父母版)对患儿行为变化进行定量评估,并将疗效分为缓解、有效和无效。检测COMT基因rs4680(Val158Met)和rs165599多态性,比较不同基因型患儿的疗效。结果 rs4680不同基因型患儿治疗效果的差异有统计学意义(P0.01):G/G型缓解38例(40.9%),有效19例(20.4%),无效36例(38.7%);G/A型缓解35例(48.6%),有效16例(22.2%),无效21例(29.2%);而A/A型缓解仅1例(100%),有效0例,无效9例(90.0%)。不同基因型患儿ADHD诊断量表总分、注意缺陷分和多动冲动分治疗前后变化值的差异有统计学意义(P0.05),G/-型比A/A型量表得分的变化更大(P0.05)。而rs165599不同基因型患儿疗效差异无统计学意义(P0.05)。结论 COMT基因rs4680(Val158Met)多态性与哌甲酯治疗反应存在关联,rs4680的G等位基因携带者治疗反应优于A/A基因型者。
[Abstract]:Objective to investigate the effect of catechol-O-methyltransferase (catechol-O-Methyltransferase,COMT) gene polymorphism on the efficacy of methyl piperate in children with attention deficit hyperactivity disorder (attention deficit hyperactivity disorder,ADHD). Methods 177 children with ADHD of Han nationality were treated with open dose titration of methyl piperate for 2 weeks and 4 weeks to obtain the best therapeutic response. Before and after treatment, ADHD diagnostic scale (parental version) was used to quantitatively evaluate the behavioral changes of children, and the curative effect was divided into remission, effective and ineffective. Rs4680 (Val158Met) and rs165599 polymorphism of COMT gene were detected to compare the efficacy of different genotypic children. Results there were significant differences in the therapeutic effect of different rs4680 genotypic children (P 0.01): 38 cases (40.9%) were relieved by G / G type, 19 cases (20.4%) were effective and 36 cases (38.7%) were ineffective. 35 cases (48.6%) were relieved, 16 cases (22.2%) were effective and 21 cases (29.2%) were ineffective, while only 1 case (100%) was effective, 0 cases were effective and 9 cases (90.0%) were ineffective. There were significant differences in the total score of ADHD diagnostic scale, attention deficit score and hyperactivity impulse score before and after treatment (P 0.05). The score of G / A scale changed more significantly than that of A / A scale (P 0.05). However, there was no significant difference in curative effect among children with different rs165599 genotypes (P 0.05). Conclusion the rs4680 (Val158Met) polymorphism of COMT gene is associated with the therapeutic response of methyl piperate. The therapeutic response of G allele carriers of rs4680 is better than that of A 鈮，
本文编号：2484825
[Abstract]:Objective to investigate the effect of catechol-O-methyltransferase (catechol-O-Methyltransferase,COMT) gene polymorphism on the efficacy of methyl piperate in children with attention deficit hyperactivity disorder (attention deficit hyperactivity disorder,ADHD). Methods 177 children with ADHD of Han nationality were treated with open dose titration of methyl piperate for 2 weeks and 4 weeks to obtain the best therapeutic response. Before and after treatment, ADHD diagnostic scale (parental version) was used to quantitatively evaluate the behavioral changes of children, and the curative effect was divided into remission, effective and ineffective. Rs4680 (Val158Met) and rs165599 polymorphism of COMT gene were detected to compare the efficacy of different genotypic children. Results there were significant differences in the therapeutic effect of different rs4680 genotypic children (P 0.01): 38 cases (40.9%) were relieved by G / G type, 19 cases (20.4%) were effective and 36 cases (38.7%) were ineffective. 35 cases (48.6%) were relieved, 16 cases (22.2%) were effective and 21 cases (29.2%) were ineffective, while only 1 case (100%) was effective, 0 cases were effective and 9 cases (90.0%) were ineffective. There were significant differences in the total score of ADHD diagnostic scale, attention deficit score and hyperactivity impulse score before and after treatment (P 0.05). The score of G / A scale changed more significantly than that of A / A scale (P 0.05). However, there was no significant difference in curative effect among children with different rs165599 genotypes (P 0.05). Conclusion the rs4680 (Val158Met) polymorphism of COMT gene is associated with the therapeutic response of methyl piperate. The therapeutic response of G allele carriers of rs4680 is better than that of A 鈮，
本文编号：2484825
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