老年痴呆患者血清同型半胱氨酸水平及临床意义

发布时间：2019-06-05 12:32

【摘要】：目的通过检测老年性痴呆患者血清同型半胱氨酸(Hcy)水平,探讨高同型半胱氨酸血症(HHcy)对老年性痴呆发生发展的临床意义。方法利用简易智能精神状态量表(MMSE)、日常生活能力量表(ADL)等将受试对象分为两组,即轻度认知功能障碍(MCI)和阿尔茨海默病(AD)组,其中MCI组29例,AD组32例,30例选自体检中心的健康体检者作为正常对照组,比较各组之间血清Hcy、叶酸和维生素B12以及血糖、总胆固醇、甘油三酯水平有无差异。结果 MCI组Hcy(17.52±4.38)μmol/L与AD组Hcy(21.46±9.22)μmol/L明显高于对照组Hcy(15.06±4.39)μmol/L浓度(分别为P=0.035,P=0.001);AD组与MCI组Hcy浓度有显著差异(P=0.04);各组的叶酸、维生素B12、血糖、总胆固醇、甘油三酯无差异(P0.05)。结论 HHcy是老年性痴呆的危险因素之一,老年性痴呆患者的病情严重程度与血清Hcy浓度具有一定的相关性。
[Abstract]:Objective to investigate the clinical significance of hyperhomocysteinemia (HHcy) in the occurrence and development of Alzheimer's disease (AD) by measuring the level of serum homocysteinemia (Hcy) in patients with Alzheimer's disease (AD). Methods the subjects were divided into two groups: mild cognitive impairment (MCI) group and Alzheimer's disease (AD) group, including 29 cases in MCI group and 32 cases in AD group. Serum Hcy, folic acid, vitamin B12, blood glucose, total cholesterol and triglyceride levels were compared among 30 healthy subjects selected from the physical examination center as normal control group. Results the concentrations of Hcy (17.52 卤4.38) 渭 mol/L and Hcy (21.46 卤9.22) 渭 mol/L in MCI group and AD group were significantly higher than those in control group (15.06 卤4.39) 渭 mol/L (P 鈮，

本文编号：2493531