青少年暴力行为与多巴胺β羟化酶基因多态性的关联分析

发布时间：2019-06-08 12:02

【摘要】：目的探讨青少年暴力行为与多巴胺β羟化酶(DβH)基因rs1611115和rs739398多态性的关系。方法将新入少教所的男性服教人员分为暴力组(107例)和非暴力组(107例),另以107例职高男生作对照组,利用SNaPshot单核苷酸多态性(SNP)分型技术对3组进行多态性的基因分型,并比较3组各基因型及等位基因频率分布差异。结果 3组在DβH基因rs1611115位点基因型及基因频率差异均有统计学意义(P0.05);两两比较显示暴力组与非暴力组在rs1611115位点基因型和等位基因频率差异无统计学意义(P0.05);与对照组比较差异均有统计学意义(P0.01)。3组在DβH基因rs739398位点基因型和基因频率差异无统计学意义(P0.05)。两两比较差异也均无统计学意义(P0.05)。结论暴力、非暴力犯罪与DβH基因rs1611115多态性均存在关联,未发现与DβH基因rs739398多态性与之存在关联。
[Abstract]:Objective to investigate the relationship between violence in adolescents and dopamine 尾 hydroxylase (D 尾 H) gene rs1611115 and rs739398 polymorphism. Methods the male teaching staff newly admitted to juvenile education institutions were divided into violence group (107 cases) and non-violence group (107 cases), and 107 male students of vocational high school were used as control group. The genotyping of polymorphism in the three groups was carried out by SNaPshot single nucleotides polymorphism (SNP) typing technique, and the differences of genotypic and allelic frequency distribution among the three groups were compared. Results there were significant differences in rs1611115 genotype and gene frequency of D 尾 H gene among the three groups (P 0.05), but there was no significant difference in rs1611115 genotype and allele frequency between violence group and non-violence group (P 0.05). Compared with the control group, there was significant difference between the three groups (P 0.01). There was no significant difference in the rs739398 genotype and gene frequency of D 尾 H gene among the three groups (P 0.05). There was no significant difference between the two groups (P 0.05). Conclusion violence and non-violent crime are associated with rs1611115 polymorphism of D 尾 H gene, but no association with rs739398 polymorphism of D 尾 H gene is found.
【作者单位】：重庆医科大学附属第一医院心理卫生中心;四川省人民医院心身医学中心;
【分类号】：R749.94

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