基于Freesurfer技术在PTSD脑部结中的研究应用

发布时间：2019-06-17 17:26

【摘要】：研究背景：先前研究发现创伤后应激障碍患者脑部有异常改变，但是国内外几乎没有文章报道创伤后应激障碍患者的脑部皮质厚度的改变。本研究的目的在于测量比较创伤后应激障碍患者，幸存者及正常对照组之间的皮质厚度差异，从而发现创伤后应激障碍患者脑部皮质厚度变化与其症状，和内部网络之间的联系。方法：利用3T磁共振采集在煤矿透水事故救上的幸存者高分辨T1加权成像图，其中包括15名创伤后应激障碍患者，10名受刺激没有发病的，以及25名正常对照组。利用表面处理法比较3组之间的皮质厚度差别，并对有差异区做局部相关处理。结果：PTSD患者与正常对照组相比，在双侧顶叶，额叶，海马区，以及扣带回和右侧枕叶皮质厚度均有减少，在距状裂有代偿性升高，且PTSD患者脑部改变区域较有刺激而未患PTSD幸存者更多，在感兴趣区比较研究中发现，，在受创伤的幸存者，扣带前回，后回，前额叶，海马区均与临床CAPS积分有统计学负相关，距状裂有正相关。结论：本研究发现早期阶段的PTSD患者不但在额颞连接网络皮质厚度有所减少，而且在边缘系统皮质有更多的减少。这些结果为早期PTSD脑部皮质的减少与应激之间的关系提供有利的影像学依据，为PTSD的临床诊断和治疗提供影像学指导。
[Abstract]:Background: previous studies have found abnormal changes in the brain of patients with post-traumatic stress disorder, but there are few articles at home and abroad on the changes of cerebral cortical thickness in patients with post-traumatic stress disorder. The purpose of this study was to measure and compare the cortical thickness between patients with post-traumatic stress disorder (PTSD), survivors and normal controls, so as to find the relationship between the changes of cortical thickness and its symptoms and internal network in patients with PTSD. Methods: high resolution T1 weighted imaging of survivors in coal mine permeable accident was collected by 3T magnetic resonance imaging, including 15 patients with post-traumatic stress disorder, 10 patients without stimulation and 25 normal controls. The difference of cortical thickness between the three groups was compared by surface treatment, and the local correlation treatment was performed on the difference area. Results: compared with the normal control group, the thickness of bilateral parietal lobe, frontalis, hippocampus, cingulate gyrus and right occipital cortex decreased, and there was a compensated increase in talus fissure, and there were more PTSD survivors in PTSD patients than in normal controls. In the comparative study of the area of interest, it was found that in the injured survivors, anterior cingulate gyrus, posterior cingulate gyrus, prefrontal lobe, The hippocampal area was negatively correlated with clinical CAPS score and positively correlated with talus fissure. Conclusion: in the early stage of PTSD, not only the thickness of frontotemporal network cortex decreased, but also more in the limbic cortex. These results provide favorable imaging basis for the relationship between cerebral cortex reduction and stress in early PTSD, and provide imaging guidance for clinical diagnosis and treatment of PTSD.
【学位授予单位】：第四军医大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R749.5

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