双相I型障碍缓解期患者与抑郁发作期患者的神经认知功能
发布时间：2019-06-20 00:19
【摘要】：目的:比较双相I型障碍(BD)患者缓解期与抑郁发作期的神经认知功能。方法:选取符合美国精神障碍统计与诊断手册第4版(DSM-IV)诊断标准的BD缓解期患者29例、BD抑郁发作期患者30例及健康对照27例,使用精神分裂症认知功能成套测验-共识版(MCCB),对三组的持续注意、学习、记忆、精细动作、社会认知、执行功能及信息处理速度7个领域的神经认知特点进行比较。归纳BD缓解期组和抑郁发作期组的首次抑郁发作年龄、终生抑郁发作次数、首次躁狂发作年龄、终生躁狂发作次数、家族史及临床用药等临床指标的特征;用汉密顿抑郁量表(HAMD)、大体功能评定量表(GAF)评定抑郁和功能情况。结果:BD缓解期组HAMD得分低于BD抑郁发作期组[(4.1±2.9)vs.(17.6±3.3),P0.01],而GAF得分高于BD抑郁发作组[(70.6±14.0)vs.(57.8±11.2),P0.01]。BD缓解期和BD抑郁发作期患者的MCCB记忆、精细动作、执行功能及总体认知功能得分低于健康对照组[(46.8±4.7)vs.(49.7±4.3),(45.4±6.0)vs.(49.7±4.3);均P0.05];BD缓解期患者的词语记忆测验得分低于BD抑郁发作期患者[(45.6±9.3)vs.(51.4±8.3),P0.05],沟槽钉板非利手测验得分高于BD抑郁发作组[(44.5±10.9)vs.(37.6±12.4),P0.05];两组其他认知测验结果差异无统计学意义。结论:BD缓解期及抑郁发作期患者均存在认知功能受损,BD缓解期患者词语记忆能力比抑郁发作期患者差,非利手精细运动能力优于抑郁发作期患者,提示神经认知功能缺损可能是BD的素质性指标之一。
[Abstract]:Objective: to compare the neurocognitive function between remission and depression in patients with biphasic type I disorder (BD). Methods: 29 patients with remission of BD, 30 patients with BD depression and 27 healthy controls were selected according to the diagnostic criteria of American Mental Disorder Statistics and Diagnostic Manual (DSM-IV). The continuous attention, learning, memory, fine action and social cognition of the three groups were studied by cognitive function test-consensus version (MCCB),. The neurocognitive characteristics of executive function and information processing speed were compared. The age of first depressive attack, the number of lifelong depressive attack, the age of first manic attack, the number of lifelong manic attack, family history and clinical medication were summarized in BD remission group and depressive attack group, and depression and function were evaluated by Hamilton depression scale (HAMD), gross function rating scale (GAF). Results: the score of HAMD in BD remission group was lower than that in BD depression attack group [(4.1 卤2.9) vs. (17.6 卤3.3), P 0.01], while the GAF score in BD depression attack group was higher than that in BD depression attack group [(70.6 卤14.0) vs. (57.8 卤11.2), P 0.01]. MCCB memory and fine movement in BD remission stage and BD depression attack group. The scores of executive function and overall cognitive function in the control group were lower than those in the healthy control group [(46.8 卤4.7) vs. (49.7 卤4.3), (45.4 卤6.0) vs. (49.7 卤4.3)]. The scores of word memory test in BD remission stage were lower than those in BD depression attack group [(45.6 卤9.3) vs. (51.4 卤8.3), P 0.05], and the score of grooving nailboard non-use hand test was higher than that in BD depression attack group [(44.5 卤10.9) vs. (37.6 卤12.4), P 0.05]. There was no significant difference in other cognitive tests between the two groups. Conclusion: cognitive impairment exists in patients with BD in remission stage and depression attack stage. The ability of word memory in patients with BD remission stage is worse than that in patients with depression attack stage, and the fine motor ability of non-use hand is better than that in patients with depression attack stage, suggesting that neurocognitive deficit may be one of the prime indexes of BD.
【作者单位】： 北京大学第六医院;北京大学精神卫生研究所;卫生部精神卫生学重点实验室(北京大学);
【基金】：北京市科委首都特色临床应用研究Z121107001012040
【分类号】：R749.4
[Abstract]:Objective: to compare the neurocognitive function between remission and depression in patients with biphasic type I disorder (BD). Methods: 29 patients with remission of BD, 30 patients with BD depression and 27 healthy controls were selected according to the diagnostic criteria of American Mental Disorder Statistics and Diagnostic Manual (DSM-IV). The continuous attention, learning, memory, fine action and social cognition of the three groups were studied by cognitive function test-consensus version (MCCB),. The neurocognitive characteristics of executive function and information processing speed were compared. The age of first depressive attack, the number of lifelong depressive attack, the age of first manic attack, the number of lifelong manic attack, family history and clinical medication were summarized in BD remission group and depressive attack group, and depression and function were evaluated by Hamilton depression scale (HAMD), gross function rating scale (GAF). Results: the score of HAMD in BD remission group was lower than that in BD depression attack group [(4.1 卤2.9) vs. (17.6 卤3.3), P 0.01], while the GAF score in BD depression attack group was higher than that in BD depression attack group [(70.6 卤14.0) vs. (57.8 卤11.2), P 0.01]. MCCB memory and fine movement in BD remission stage and BD depression attack group. The scores of executive function and overall cognitive function in the control group were lower than those in the healthy control group [(46.8 卤4.7) vs. (49.7 卤4.3), (45.4 卤6.0) vs. (49.7 卤4.3)]. The scores of word memory test in BD remission stage were lower than those in BD depression attack group [(45.6 卤9.3) vs. (51.4 卤8.3), P 0.05], and the score of grooving nailboard non-use hand test was higher than that in BD depression attack group [(44.5 卤10.9) vs. (37.6 卤12.4), P 0.05]. There was no significant difference in other cognitive tests between the two groups. Conclusion: cognitive impairment exists in patients with BD in remission stage and depression attack stage. The ability of word memory in patients with BD remission stage is worse than that in patients with depression attack stage, and the fine motor ability of non-use hand is better than that in patients with depression attack stage, suggesting that neurocognitive deficit may be one of the prime indexes of BD.
【作者单位】： 北京大学第六医院;北京大学精神卫生研究所;卫生部精神卫生学重点实验室(北京大学);
【基金】：北京市科委首都特色临床应用研究Z121107001012040
【分类号】：R749.4
【参考文献】
相关期刊论文 前2条
1 张明园;;大体评定量表(GAS)[J];上海精神医学;1984年02期
2 曹莉萍;林鄞;李p，
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