精神分裂症患者攻击行为与甲状腺激素、睾酮的相关性

发布时间：2019-07-02 12:01

【摘要】：目的:探讨血清甲状腺激素和血清睾酮与精神分裂症患者攻击行为的相关性。方法:依据既往暴力史及外显攻击行为量表(MOAS)评分区分攻击组40例和非攻击组40例。比较两组促甲状腺激素(TSH)、血清游离三碘甲状腺原氨酸(FT3)、血清游离甲状腺素(FT4)、总三碘甲状腺原氨酸(TT3)、总甲状腺激素(TT4)及血清睾酮(Testo)水平。攻击组MOAS总分及各因子分与血清TSH、FT3、FT4、TT3、TT4及血清睾酮水平之间作相关分析。结果:攻击组在TSH、FT3、TT3、男性睾酮上高于非攻击组(P0.05或P0.01),在TT4上低于非攻击组(P0.01);攻击组TSH、男性睾酮与MOAS对他人攻击因子分呈正相关(P0.05),攻击组FT3与MOAS的自身攻击因子分呈正相关(P0.05),攻击组TT4与言语攻击因子分呈负相关(P0.05)。结论:精神分裂症患者攻击行为与TSH、FT3水平的变化呈正相关,与TT4水平变化呈负相关,男性精神分裂症患者攻击行为与睾酮水平的变化呈正相关。
[Abstract]:Objective: to investigate the relationship between serum thyroid hormone and serum testosterone and aggressive behavior in patients with schizophrenia. Methods: 40 cases in attack group and 40 cases in non-aggression group were distinguished according to the past violence history and explicit aggression behavior scale (MOAS) score. The levels of serum free triiodothyronine (FT3), serum free thyroxine (FT4), total triiodothyronine (TT3), total thyroid hormone (TT4) and serum testosterone (Testo) were compared between the two groups. The total score of MOAS and the scores of each factor in the attack group were correlated with serum TSH,FT3,FT4,TT3,TT4 and serum testosterone levels. Results: the testosterone of TSH,FT3,TT3, male in attack group was higher than that in non-attack group (P 0.05 or P 0.01), and it was lower in TT4 group than that in non-attack group (P 0.01). There was a positive correlation between testosterone and MOAS aggression factor score in attack group (P 0.05), a positive correlation between FT3 and MOAS aggression factor score in attack group (P 0.05), and a negative correlation between TT4 and speech attack factor score in attack group (P 0.05). Conclusion: aggressive behavior is positively correlated with the change of TSH,FT3 level, negatively correlated with the change of TT4 level, and positively correlated with the change of testosterone level in male patients with schizophrenia.
【作者单位】：大连市第七人民医院;
【分类号】：R749.3

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