社交沟通问卷在孤独症谱系障碍一级筛查中的应用

发布时间：2019-07-08 15:18

【摘要】：孤独症谱系障碍是一类以社会交往障碍为核心表现的儿童脑发育疾病.近年来,孤独症谱系障碍的早期筛查已得到广泛的研究.本研究旨在探讨社交沟通问卷在孤独症谱系障碍一级筛查中的应用情况.选取上海市4家幼儿园的学龄前期儿童作为筛查对象,运用社交沟通问卷对其进行孤独症谱系障碍的筛查.结果发现,2名儿童为孤独症谱系障碍疑似患儿,疑似患病率为2.3/1000.选择孤独症谱系障碍患儿为病例组,所有参与问卷一级筛查的非孤独症儿童为对照组,计算问卷的灵敏度和特异度.结果显示,问卷灵敏度和特异度分别为0.74和0.93.对问卷得分在普通人群中的分布及问卷项目的回答模式进行分析,结果发现,普通人群中社会沟通能力问卷(SCQ)总分为0~20,x为8.74±3.9,呈近似正态分布.超过70%的对照组儿童在SCQ量表一些问题的评定上呈孤独症阳性并且项目回答阳性率高于病例组.综上所述,SCQ手册所推荐的问卷截断值可能并不适合于一级筛查,适当降低问卷的截断值可能会提高问卷的有效性.问卷中的一些项目并不能很好地区分孤独症谱系障碍儿童和其他儿童.
文内图片：

图片说明：SCQ量表总分分布
[Abstract]:Autism spectrum disorder is a kind of child's brain development disease which is characterized by social communication disorder. In recent years, the early screening of autism spectrum disorders has been widely studied. The purpose of this study is to explore the application of social communication questionnaire in the screening of autism spectrum disorders. The preschool children in four kindergartens in Shanghai were selected as the screening target, and the social communication questionnaire was used to screen the autism spectrum disorder. As a result,2 children were suspected of autism spectrum disorders, with a suspected prevalence of 2.3/1000. The patients with autism spectrum disorder were selected as the case group, and all the non-autistic children participating in the first-level screening of the questionnaire were the control group, and the sensitivity and specificity of the questionnaire were calculated. The results showed that the sensitivity and specificity of the questionnaire were 0.74 and 0.93, respectively. The distribution of the questionnaire score in the general population and the response pattern of the questionnaire project were analyzed. The results showed that the social communication ability questionnaire (SCQ) in the general population was divided into 0-20, x was 8.74-3.9, and the distribution was approximately normal distribution. More than 70% of the children in the control group were autistic and the positive rate of the response of the project was higher than that of the case group. In conclusion, the cut-off value recommended by the SCQ manual may not be appropriate for primary screening, and the appropriate reduction in the cutoff value of the questionnaire may increase the effectiveness of the questionnaire. Some of the projects in the questionnaire are not well distributed to children and other children with autism spectrum disorders.
【作者单位】：复旦大学附属儿科医院儿童保健科;
【基金】：上海市公共卫生人才培养计划(批准号:GWDTR201220) 上海市公共卫生重点学科项目(批准号:12GWZX0301)资助
【分类号】：R749.94

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