氯胺酮为麻醉剂的无抽搐电休克治疗对难治性抑郁症患者血清BDNF水平的影响
发布时间：2019-07-21 19:34
【摘要】：目的探讨以氯胺酮为麻醉剂的无抽搐电休克(MECT)治疗难治性抑郁症患者的疗效及与脑源性神经营养因子(BDNF)含量变化的相关性。方法将60例难治性抑郁症患者随机分为氯胺酮组及丙泊酚组(各30例)分别使用氯胺酮、丙泊酚作为麻醉剂进行MECT治疗。所有患者在MECT治疗前及治疗1~8次后完成汉密尔顿抑郁量(HAMD)、认知功能及不良反应量表(TESS)评定,抽血测BDNF浓度。结果两组在治疗后HAMD总分均明显下降(P0.01),而氯胺酮组在治疗第1次开始减分优于丙泊酚组(P0.01);氯胺酮组从治疗第4次开始血清BDNF浓度明显升高(P0.01),丙泊酚组治疗前后无明显变化;MECT治疗后血清BDNF浓度与HAMD总分呈显著负相关(r=-0.368,P0.01)。结论氯胺酮作为MECT麻醉剂治疗难治性抑郁症安全、有效,且患者BDNF水平随抑郁程度好转而升高。
[Abstract]:Objective to investigate the efficacy of non-convulsive electroconvulsive (MECT) with ketamine as anesthetic in the treatment of refractory depression and its correlation with the content of brain-derived neurotrophic factor (BDNF). Methods 60 patients with refractory depression were randomly divided into ketamine group (n = 30) and propofol group (n = 30). Ketamine and propofol were used as anesthetics for MECT. Before and after MECT treatment, all patients completed Hamilton depression (HAMD), cognitive function and adverse reaction scale (TESS) assessment, and blood samples were taken to measure the concentration of BDNF. Results after treatment, the total score of HAMD in ketamine group was significantly lower than that in propofol group (P 0.01), and the serum BDNF concentration in ketamine group was significantly higher than that in propofol group (P 0.01) from the 4th time of treatment, but there was no significant change in propofol group before and after treatment. There was a significant negative correlation between serum BDNF concentration and HAMD total score after MECT treatment (r 鈮，
本文编号：2517370
[Abstract]:Objective to investigate the efficacy of non-convulsive electroconvulsive (MECT) with ketamine as anesthetic in the treatment of refractory depression and its correlation with the content of brain-derived neurotrophic factor (BDNF). Methods 60 patients with refractory depression were randomly divided into ketamine group (n = 30) and propofol group (n = 30). Ketamine and propofol were used as anesthetics for MECT. Before and after MECT treatment, all patients completed Hamilton depression (HAMD), cognitive function and adverse reaction scale (TESS) assessment, and blood samples were taken to measure the concentration of BDNF. Results after treatment, the total score of HAMD in ketamine group was significantly lower than that in propofol group (P 0.01), and the serum BDNF concentration in ketamine group was significantly higher than that in propofol group (P 0.01) from the 4th time of treatment, but there was no significant change in propofol group before and after treatment. There was a significant negative correlation between serum BDNF concentration and HAMD total score after MECT treatment (r 鈮，
本文编号：2517370
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