双歧杆菌三联活菌胶囊辅助治疗伴有焦虑抑郁的幽门螺杆菌阳性慢性萎缩性胃炎的临床观察

发布时间：2019-07-31 14:51

【摘要】：目的:观察双歧杆菌三联活菌胶囊辅助治疗伴有焦虑抑郁的幽门螺杆菌(Hp)阳性慢性萎缩性胃炎(CAG)的临床疗效及安全性。方法:将伴有焦虑抑郁的Hp阳性CAG患者100例按随机数字表法分为对照组和观察组,各50例。对照组患者给予标准三联疗法(雷贝拉唑+阿莫西林克拉维酸+左氧氟沙星)治疗;观察组患者在对照组基础上加用双歧杆菌三联活菌胶囊0.42 g,tid。两组患者疗程均为14 d。观察两组患者临床疗效、Hp根除率及治疗前后汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)评分,并比较不良反应发生情况。结果:观察组患者临床总有效率为94.0%、Hp根除率为92.0%,明显高于对照组的76.0%与78.0%,差异均有统计学意义(P0.05)。治疗前,两组患者HAMA、HAMD评分比较,差异均无统计学意义(P0.05);治疗后,两组患者HAMA、HAMD评分显著降低,且观察组评分显著低于对照组,差异均有统计学意义(P0.05)。观察组患者不良反应发生率为4.0%,显著低于对照组的20.0%,差异有统计学意义(P0.05)。结论:双歧杆菌三联活菌胶囊辅助治疗伴有焦虑抑郁的Hp阳性CAG疗效显著,可显著提高Hp根除率,明显改善患者焦虑抑郁状态,降低不良反应发生率。
[Abstract]:Objective: To observe the efficacy and safety of bifidobacterium triple viable capsule in the treatment of Helicobacter pylori (Hp) positive chronic atrophic gastritis (CAG) with anxiety and depression. Methods:100 patients with Hp positive CAG with anxiety and depression were divided into control group and observation group according to the random number table method. The patients in the control group were treated with standard triple therapy (rebelline + amoxicillin clavulanic acid + levofloxacin); the patients in the observation group were treated with bifidobacterium triple viable capsules 0.42 g, tid on the basis of the control group. The clinical efficacy, the eradication rate of Hp and the Hamilton anxiety scale (HAMA), the Hamilton Depression Scale (HAMD) and the incidence of adverse reactions were observed in the two groups. Results: The clinical total effective rate of the observation group was 94.0%, and the eradication rate of Hp was 92.0%, which was significantly higher than that of the control group (76.0% and 78.0%) (P <0.05). The scores of HAMA and HAMD in the two groups had no significant difference before treatment (P0.05). After the treatment, the scores of HAMA and HAMD in the two groups were significantly lower, and the scores of the observation group were significantly lower than that of the control group (P0.05). The incidence of adverse reactions in the observation group was 4.0%, which was significantly lower than that in the control group (P <0.05). Conclusion: The therapeutic effect of bifidobacteria triple viable capsule on the treatment of Hp-positive CAG with anxiety and depression can significantly improve the Hp eradication rate, improve the anxiety and depression status of the patients, and reduce the incidence of adverse reactions.
【作者单位】：南京市溧水区人民医院消化科;
【基金】：南京市医学科技发展项目(No.YKK14199)
【分类号】：R573.32;R749

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