应用帕罗西汀治疗抑郁症的疗效分析及安全性评估

发布时间：2019-08-03 07:00

【摘要】：本研究试图通过对帕罗西汀治疗抑郁症的疗效分析及安全性评估,为抑郁症的临床药物选择提供依据。将140例确诊为抑郁症的患者分为试验组70例和对照组70例。两组患者均采取口服药物治疗,试验组患者接受帕罗西汀口服,对照组患者接受氟西汀口服,以6周作为一个治疗周期。治疗前后采用HAMD量表与HAMA量表进行得分,采用副反应量表(TESS)及通过血液检查评价治疗的安全性。发现组内与治疗前比较,两组治疗后每个时间节点的HAMD与HAMA量表得分均显著降低(p0.05);同时组间与对照组比较,试验组在治疗后的每个时间节点时的HAMD与HAMA量表得分均显著降低(p0.05);在治愈率和总有效率方面,试验组高于对照组,而在总不良反应发生率方面,试验组低于对照组(p0.05)。可见与氟西汀相比,帕罗西汀治疗抑郁症更加有效及安全。
[Abstract]:This study attempts to provide evidence for clinical drug selection of depression by analyzing the efficacy and safety of paroxetine in the treatment of depression. 140 patients with depression were divided into experimental group (n = 70) and control group (n = 70). Both groups were treated with oral drugs, the experimental group was treated with paroxetine, and the control group was treated with fluoxetine for 6 weeks as a treatment cycle. Before and after treatment, HAMD scale and HAMA scale were used to score, side effects scale (TESS) and blood test were used to evaluate the safety of the treatment. It was found that the scores of HAMD and HAMA at each time node in the two groups were significantly lower than those before treatment (p0.05), and the scores of HAMD and HAMA in the experimental group were significantly lower than those in the control group at each time node after treatment (p0.05). In terms of cure rate and total effective rate, the rate of total adverse reactions in the experimental group was higher than that in the control group, while the incidence of total adverse reactions in the experimental group was lower than that in the control group (p0.05). It can be seen that paroxetine is more effective and safe in the treatment of depression than fluoxetine.
【作者单位】：兴安职业技术学院医学分院;
【基金】：兴安职业技术学院医学分院资助
【分类号】：R749.4

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