慢性牙周炎患者血清中C-反应蛋白和类风湿因子的关联研究

发布时间：2018-05-22 20:16

本文选题：慢性牙周炎 + C-反应蛋白　；参考：《河北联合大学》2014年硕士论文

【摘要】：背景慢性牙周炎（chronic periodontitis，CP）是我国成年人丧失牙齿的首位原因。类风湿性关节炎（Rheumatoid arthritis，RA）是一类发病机制尚未完全阐明的自身免疫性疾病。研究证明，牙周炎和类风湿性关节炎二者在免疫病理学上有许多相似之处，由于牙周炎和类风湿性关节炎是如此类似，有学者甚至认为他们是同一类疾病。近年来研究的热点在于牙周炎与类风湿性关节炎在临床上的相关性。目的本研究通过比较慢性牙周炎患者和健康人群中血清中C-反应蛋白（C-Reactive Protein，，CRP）和类风湿因子（Rheumatoid Factor，RF）的浓度水平，研究慢性牙周炎患者与健康人群的类风湿因子及C-反应蛋白水平的状况，进而进一步分析了慢性牙周炎与类风湿性关节炎的关联。本文将针对慢性牙周炎与类风湿性关节炎疾病在临床上的关系进行研究。方法本研究在获得患者知情同意并签署同意书的基础上，进行了血清相关因子的医学检测。研究对象选择慢性牙周炎患者和健康人群，采集研究对象的静脉血，进行血清CRP及RF的检测。针对采集到的血清检测得出的CRP及RF水平的数据：慢性牙周炎组数据（41组）健康对照组（54组）慢性牙周炎牙周系统治疗后3个月（11组），对其进行研究，运用统计学软件SPSS13.0，针对两组数据进行概况分析，探讨了静脉血血清中CRP和RF水平与慢性牙周炎的关联性。在此基础上，通过多种回归分析模型进行研究，探讨血清中C-反应蛋白与类风湿性因子的关系。结合慢性牙周炎患者的特点，分析了慢性牙周炎与类风湿性关节炎的关系。结果1健康组及慢性牙周炎组血清中C-反应蛋白及类风湿因子均呈现较强的相关性，表明二者之间存在某种关联；2通过多种回归分析，牙周炎组中C-反应蛋白及类风湿因子的回归结果不明确，而健康组血清中二者呈现线性关联性，即C-反应蛋白水平随着类风湿因子水平的增高而增高；3慢性牙周炎组的C-反应蛋白水平及类风湿因子平均水平均高于健康组，推断结果表明，慢性牙周炎疾病增高了血清中C-反应蛋白的水平，也影响了患者的类风湿因子水平。慢性牙周炎与类风湿性关节炎可能存在关联；4由于牙周炎组血清中C-反应蛋白受身体多种因素的影响，且各因素对其的影响程度尚不明确，导致C-反应蛋白及类风湿因子的关联性不明朗，其内在关系，还有待于进一步的深入研究；5慢性牙周炎患者经过系统牙周治疗3个月后，其C-反应蛋白平均水平由4.2下降到2.55，类风湿因子水平由9.23下降到8.79。结论本研究根据临床血清检测的结果进行分析，通过C-反应蛋白与类风湿因子的相关性研究，揭示了牙周炎与类风湿性关节炎具有临床上的关联性。
[Abstract]:Background chronic periodontitis chronic periodontis (CPD) is the leading cause of tooth loss in Chinese adults. Rheumatoid arthritis (RA) is an autoimmune disease whose pathogenesis has not been fully elucidated. Studies have shown that periodontitis and rheumatoid arthritis have many similarities in immunopathology, because periodontitis and rheumatoid arthritis are so similar, some scholars even think they are the same disease. The focus of research in recent years is the clinical correlation between periodontitis and rheumatoid arthritis. Objective to compare the levels of serum C-reactive protein (CRP) and rheumatoid factoroid (RF) in patients with chronic periodontitis and healthy subjects. To study the level of rheumatoid factor and C-reactive protein in patients with chronic periodontitis and healthy people, and further analyze the association between chronic periodontitis and rheumatoid arthritis. The relationship between chronic periodontitis and rheumatoid arthritis is studied. Methods on the basis of obtaining the informed consent and signing the consent form, the serum related factors were detected. Patients with chronic periodontitis and healthy people were selected and their venous blood was collected to detect serum CRP and RF. According to the data of serum CRP and RF levels: chronic periodontitis group (41 groups) healthy control group (54 groups) chronic periodontitis periodontal system treatment 3 months after 11 groups, the study was carried out. The relationship between serum CRP and RF levels in venous blood and chronic periodontitis was studied by SPSS 13.0 software. On this basis, the relationship between serum C-reactive protein and rheumatoid factor was studied by multiple regression models. The relationship between chronic periodontitis and rheumatoid arthritis was analyzed. Results (1) there was a strong correlation between serum C-reactive protein and rheumatoid factor in healthy group and chronic periodontitis group, indicating that there was a certain correlation between them by multiple regression analysis. The regression results of C- reactive protein and rheumatoid factor in periodontitis group were not clear, but there was a linear correlation between them in serum of healthy group. That is to say, the level of C-reactive protein and the average level of rheumatoid factor in patients with chronic periodontitis increased with the increase of rheumatoid factor level. Chronic periodontitis increased the level of serum C-reactive protein and affected the level of rheumatoid factor. Chronic periodontitis may be associated with rheumatoid arthritis because the serum C-reactive protein in periodontitis group is affected by many factors of the body, and the influence of each factor on it is not clear. The relationship between C- reactive protein and rheumatoid factor is uncertain, and the relationship between C- reactive protein and rheumatoid factor remains to be further studied after 3 months of systematic periodontal treatment in patients with chronic periodontitis. The average level of C-reactive protein decreased from 4.2 to 2.55, and the level of rheumatoid factor decreased from 9.23 to 8.79. Conclusion this study is based on the analysis of clinical serum test results, through the study of the correlation between C-reactive protein and rheumatoid factor, it is revealed that periodontitis and rheumatoid arthritis have a clinical relevance.
【学位授予单位】：河北联合大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R781.42

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