广西壮族自治区四个县0～15岁人群肠道病毒71型中和抗体水平调查

发布时间：2017-12-27 01:13

本文关键词：广西壮族自治区四个县0～15岁人群肠道病毒71型中和抗体水平调查　出处：《中国疫苗和免疫》2015年03期 　论文类型：期刊论文

【摘要】：目的了解广西壮族自治区(广西)4个县0~15岁人群的肠道病毒71型(Enterovirus Type 71,EV71)中和抗体(Neutralizing Antibody,NA)水平,为制定EV71疫苗免疫程序提供参考。方法选取广西4个县作为研究现场,在每个县选取2个乡,对调查现场的0~15岁人群采集静脉血标本。结果≤6月龄各月龄组研究对象血清EV71 NA阳性率随年龄的增长而迅速下降;直到9~11月龄仍维持在较低水平(20.0%),≥1岁各年龄组NA阳性率迅速上升,其中5岁组的EV71 NA阳性率最高(87.0%)。0~15岁人群的EV71 NA几何平均滴度(Geometric Mean Titer,GMT)为1∶18.24,新生儿EV71 NA GMT较高(1∶23.12),随着月龄增长,EV71 NA GMT逐渐下降,至5月龄降至最低(1∶5.46),≥1岁各年龄组的NA GMT迅速上升,5岁组最高(1∶95.68)。4个县及不同性别的分年龄组EV71 NA阳性率及GMT与EV71总的NA阳性率及GMT相似。结论 5~6月龄婴儿EV71 NA阳性率及GMT均降至最低水平,为确定EV71疫苗接种起始月龄提供参考。
[Abstract]:Objective to understand the level of Enterovirus Type 71 (EV71) neutralizing antibody (Neutralizing Antibody, NA) of people aged 0~15 years in 4 counties of the Guangxi Zhuang Autonomous Region (Guangxi), so as to provide reference for developing EV71 vaccine immunization procedure. Methods 4 counties in Guangxi were selected as the research sites, and 2 townships were selected in each county to collect the venous blood samples from the 0~15 years old people in the investigation site. Results the positive rate of less than June age among age groups of subjects serum EV71 NA with age decreased rapidly; until 9~11 months remained at a relatively low level (20%), more than 1 years in each age group the positive rate of NA increased rapidly, the positive rate of EV71 NA 5 years old group is the highest (87%). EV71 NA geometric mean titer of people aged 0~15 (Geometric Mean Titer, GMT) is 1: 18.24, NA GMT of neonatal EV71 (1: 23.12) higher, with the age growth, the EV71 NA GMT decreased gradually, to May to a minimum age (1 to 5.46), more than 1 years in each age group of NA GMT quickly on the rise, 5 years old was the highest (1: 95.68). The positive rate of EV71 NA and the total NA positive rate of GMT and EV71 were similar to GMT in 4 counties and different sex groups. Conclusion the positive rate of EV71 NA and GMT in 5~6 month old infants are all lower to the lowest level, which can provide a reference for determining the initial age of EV71 vaccination.
【作者单位】：中国疾病预防控制中心免疫规划中心;中国疾病预防控制中心病毒病预防控制所;传染病预防控制国家重点实验室;广西壮族自治区疾病预防控制中心;
【分类号】：R186
【正文快照】： 肠道病毒71型(Enterovirus Type 71,EV71)和柯萨奇病毒A组16型(Coxsackievirus Group A Type16,CVA16)是引起手足口病(Hand-Foot-Mouth Dis-ease,HFMD)的主要病原体。EV71具有嗜神经毒性,更易引起神经系统并发症,如无菌性脑炎、脑膜炎等,其引起的后遗症比其他病毒多见且严重[1

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